Fibroblast Growth Factor 6 Active Protein | FGF6 active protein

Fibroblast Growth Factor 6, Recombinant, Human (FGF6)

Cat. Num. AAA650527

• Gene Names: FGF6; HST2; HBGF-6
• Purity: Molecular Biology Grade; 95% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug (1EU/ug).
• Synonyms: Fibroblast Growth Factor 6; Recombinant; Human (FGF6); FGF6 active protein

• Host: E Coli
• Purity/Purification: Molecular Biology Grade; 95% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug (1EU/ug).
• Form/Format: Supplied as a lyophilized powder from 10mM Tris, pH 7.4 and 100mM sodium chloride. Reconstitute in dH2O, to 0.5-1mg/ml. This solution can then be diluted into other aqueous buffers.

• Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is 0.5 ng/ml, corresponding to a speci c activity of 2 x10e6 units/mg.
• Country of Origin: USA
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Reconstitute to nominal volume by adding sterile ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for FGF6 active protein

The FGFs play key roles in controlling tissue growth, morphogenesis and repair in animals. FGF-6 is a newly discovered heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. Recombinant Human FGF-6 is a 18.7kD protein containing 168 amino residues.

Product Categories/Family for FGF6 active protein

Growth Factors; Cytokines; Growth Factors-FGF

NCBI and Uniprot Product Information

• NCBI GI #: 15147343
• NCBI GeneID: 2251
• NCBI Accession #: NP_066276.2
• NCBI GenBank Nucleotide #: NM_020996.1
• UniProt Accession #: P10767; Q0VAE1
• Molecular Weight: 18.7kD
• NCBI Official Full Name: fibroblast growth factor 6
• NCBI Official Synonym Full Names: fibroblast growth factor 6
• NCBI Official Symbol: FGF6
• NCBI Official Synonym Symbols: HST2; HBGF-6
• NCBI Protein Information: fibroblast growth factor 6; FGF-6; HST-2; HSTF-2; OTTHUMP00000238378; heparin-binding growth factor 6; heparin secretory-transforming protein 2
• UniProt Protein Name: Fibroblast growth factor 6
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF6
• UniProt Synonym Gene Names: HST2; HSTF2
• UniProt Entry Name: FGF6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq]

Uniprot Description

Function: Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Sequence similarities: Belongs to the heparin-binding growth factors family.

Sequence caution: The sequence CAA40359.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA40360.1 differs from that shown. Reason: Erroneous initiation.