Rabbit anti-Human Thioredoxin 2 Polyclonal Antibody | anti-Trx2 antibody

Thioredoxin 2, CT (Thioredoxin, Mitochondrial, Trx2, Mt-Trx, MTRX, Thioredoxin-2, TXN2, TRX2) (PE)

Cat. Num. AAA6502469

• Gene Names: TXN2; TXN; MTRX; TRX2; MT-TRX; COXPD29
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: Thioredoxin 2; Polyclonal Antibody; CT (Thioredoxin; Mitochondrial; Trx2; Mt-Trx; MTRX; Thioredoxin-2; TXN2; TRX2) (PE); anti-Trx2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Thioredoxin 2.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-Trx2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human Trx2 (KLH).
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-Trx2-I151 Pab in 293 cell line lysate (35ug/lane). Trx2-I151 (arrow) was detected using the purified Pab.)

Product Categories/Family for anti-Trx2 antibody

Antibodies; Thioredoxin

References

1. J. Biol. Chem. 277(36), 33249-33257 (2002). 2. J. Biol. Chem. 277 (36), 33242-33248 (2002).

NCBI and Uniprot Product Information

• NCBI GI #: 21361403
• NCBI GeneID: 25828
• NCBI Accession #: NP_036605
• NCBI GenBank Nucleotide #: NM_012473.3
• UniProt Accession #: Q99757; Q5JZA0; Q6FH60; Q9UH29
• Molecular Weight: 18,383 Da
• NCBI Official Full Name: thioredoxin, mitochondrial
• NCBI Official Synonym Full Names: thioredoxin 2
• NCBI Official Symbol: TXN2
• NCBI Official Synonym Symbols: TXN; MTRX; TRX2; MT-TRX; COXPD29
• NCBI Protein Information: thioredoxin, mitochondrial
• UniProt Protein Name: Thioredoxin, mitochondrial
• Protein Family: Thioredoxin
• UniProt Gene Name: TXN2
• UniProt Synonym Gene Names: TRX2; MTRX; Mt-Trx
• UniProt Entry Name: THIOM_HUMAN

NCBI Description

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cell soma; mitochondrion; mitochondrial matrix; dendrite; nucleolus

Molecular Function: peptide-methionine-(S)-S-oxide reductase activity; protein disulfide oxidoreductase activity; protein complex binding; peptide-methionine (R)-S-oxide reductase activity

Biological Process: response to drug; response to reactive oxygen species; cellular response to nutrient levels; cell redox homeostasis; response to glucose stimulus; response to hormone stimulus; response to hypoxia; response to axon injury; response to organic cyclic substance; response to nutrient; glycerol ether metabolic process