Rabbit anti-Human SHIP Polyclonal Antibody | anti-SHIP antibody

SHIP, CT (INPP5D, SH2-containing Inositol 5-phosphatase 1, SH2 Domain-containing Inositol Phosphatase 1, SHIP-1, Inositol Polyphosphate-5-phosphatase of 145kD, SIP-145, p150Ship Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, hp51CN, SHIP1) (Max

Cat. Num. AAA6499317

• Gene Names: INPP5D; SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: SHIP; Polyclonal Antibody; CT (INPP5D; SH2-containing Inositol 5-phosphatase 1; SH2 Domain-containing Inositol Phosphatase 1; SHIP-1; Inositol Polyphosphate-5-phosphatase of 145kD; SIP-145; p150Ship Phosphatidylinositol-3; 4; 5-trisphosphate 5-phosphatase 1; hp51CN; SHIP1) (Max; anti-SHIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SHIP1.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-SHIP antibody: Immunohistochemistry (IHC), FLISA
• Application Notes: IHC: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human SHIP1 (KLH).
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-SHIP antibody

Antibodies; Enzymes; Phosphatase

References

1. Maxwell, M., et al. 2004. J. Biol. Chem. 279, 32196. 2. Giuriato, S., et al. 2003. Biochem. J. 376, 199. 3. Sly, L.M., at al. 2003. Exp. Hematol. 31, 1170. 4. Sattler, M., et al. 2001. J. Biol. Chem. 276, 2451.

NCBI and Uniprot Product Information

• NCBI GI #: 64085167
• NCBI GeneID: 3635
• NCBI Accession #: NP_001017915
• NCBI GenBank Nucleotide #: NM_001017915
• UniProt Accession #: O00145; Q92835
• Molecular Weight: 131kDa
• NCBI Official Full Name: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform a
• NCBI Official Synonym Full Names: inositol polyphosphate-5-phosphatase D
• NCBI Official Symbol: INPP5D
• NCBI Official Synonym Symbols: SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
• NCBI Protein Information: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

NCBI Description

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]