Sheep anti-Human Parathyroid Hormone Related Peptide, aa107-111 Polyclonal Antibody | anti-PTH1R antibody
Parathyroid Hormone Related Peptide, aa107-111 (Parathyroid Hormone-related Protein, PTHrP, PTH-rP, Humoral Hypercalcemia of Malignancy, HHM, MGC14611, Osteostatin, Parathyroid Hormone-like Hormone, PTHLH, Parathyroid Hormone-like Protein, Parathyroid Hor
Serum
Serum
Dilution: ELISA: 1:3000
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Description
Function: This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Ref.10 Ref.12
Subunit structure: Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1. Ref.10 Ref.12
Subcellular location: Cell membrane; Multi-pass membrane protein Ref.12.
Tissue specificity: Expressed in most tissues. Most abundant in kidney, bone and liver.
Involvement in disease: Jansen metaphyseal chondrodysplasia (JMC) [MIM:156400]: Rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.14 Ref.15 Ref.17 Ref.20Chondrodysplasia Blomstrand type (BOCD) [MIM:215045]: Severe skeletal dysplasia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16Enchondromatosis multiple (ENCHOM) [MIM:166000]: A condition characterized by multiple formation of enchondromas, benign neoplasms derived from mesodermal cells that form cartilage. Enchondromas remain within the substance of a cartilage or bone. Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.Note: The disease may be caused by mutations affecting the gene represented in this entry. Ref.18 Ref.19Eiken skeletal dysplasia (EISD) [MIM:600002]: A rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21Primary failure of tooth eruption (PFE) [MIM:125350]: Rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Belongs to the G-protein coupled receptor 2 family.
Research Articles on PTH1R
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Product Notes
The PTH1R pth1r (Catalog #AAA649744) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The Parathyroid Hormone Related Peptide, aa107-111 (Parathyroid Hormone-related Protein, PTHrP, PTH-rP, Humoral Hypercalcemia of Malignancy, HHM, MGC14611, Osteostatin, Parathyroid Hormone-like Hormone, PTHLH, Parathyroid Hormone-like Protein, Parathyroid Hor reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Parathyroid Hormone Related Peptide, aa107-111 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Dilution: ELISA: 1:3000. Researchers should empirically determine the suitability of the PTH1R pth1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Parathyroid Hormone Related Peptide, aa107-111, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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