Rabbit anti-Human PF4V1 Polyclonal Antibody | anti-PF4V1 antibody

PF4V1, CT (PF4V1, CXCL4V1, SCYB4V1, Platelet factor 4 variant, C-X-C motif chemokine 4 variant, CXCL4L1, PF4alt, PF4var1, Platelet factor 4 variant(4-74), Platelet factor 4 variant(5-74), Platelet factor 4 variant(6-74))

Cat. Num. AAA649442

• Gene Names: PF4V1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PF4V1; Polyclonal Antibody; CT (PF4V1; CXCL4V1; SCYB4V1; Platelet factor 4 variant; C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1; Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)); Anti -PF4V1; anti-PF4V1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-PF4V1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: PF4V1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-104 amino acids from the C-terminal region of human PF4V1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using MBS649442. This demonstrates MBS649442 detected the PF4V1 protein (arrow).)

Related Product Information for anti-PF4V1 antibody

PF4V1 is an inhibitor of angiogenesis and endothelial cell chemotaxis (in vitro).

Product Categories/Family for anti-PF4V1 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 4505735
• NCBI GeneID: 5197
• NCBI Accession #: NP_002611.1
• NCBI GenBank Nucleotide #: NM_002620.2
• UniProt Accession #: P10720; A1L4S0
• Molecular Weight: 11,553 Da
• NCBI Official Full Name: platelet factor 4 variant
• NCBI Official Synonym Full Names: platelet factor 4 variant 1
• NCBI Official Symbol: PF4V1
• NCBI Official Synonym Symbols: PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
• NCBI Protein Information: platelet factor 4 variant; PF4alt; PF4var1; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like)
• UniProt Protein Name: Platelet factor 4 variant
• Protein Family: Platelet factor
• UniProt Gene Name: PF4V1
• UniProt Synonym Gene Names: CXCL4V1; SCYB4V1
• UniProt Entry Name: PF4V_HUMAN

Uniprot Description

Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Ref.5

Subunit structure: Homotetramer. Ref.6

Subcellular location: Secreted.

Post-translational modification: The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).

Miscellaneous: Binding to heparin is much weaker than in the close homolog PF4/CXCL4.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Mass spectrometry: Molecular mass is 8250.9 Da from positions 31 - 104. Determined by ESI. Platelet factor 4 variant. Ref.5Molecular mass is 7877.7 Da from positions 34 - 104. Determined by ESI. Platelet factor 4 variant(4-74). Ref.5Molecular mass is 7805.8 Da from positions 35 - 104. Determined by ESI. Platelet factor 4 variant(5-74). Ref.5Molecular mass is 7678.6 Da from positions 36 - 104. Determined by ESI. Platelet factor 4 variant(6-74). Ref.5