Western Blot (WB)
(Western Blot analysis of C20orf20 expression in transfected 293T cell line by C20orf20 polyclonal antibody. Lane 1: C20orf20 transfected lysate (22.44kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human MRGBP Polyclonal Antibody | anti-MRGBP antibody
MRGBP (C20orf20, MRG-binding Protein, MRG/MORF4L-binding Protein, FLJ10914)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml
Western Blot (WB)
(Western Blot analysis of C20orf20 expression in transfected 293T cell line by C20orf20 polyclonal antibody. Lane 1: C20orf20 transfected lysate (22.44kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of C20orf20 expression in transfected 293T cell line by C20orf20 polyclonal antibody. Lane 1: C20orf20 transfected lysate (22.44kD). Lane 2: Non-transfected lysate.)
Immunohistochemistry (IHC)
(Immunoperoxidase of purified antibody to C20orf20 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3ug/ml].)
Immunohistochemistry (IHC)
(Immunoperoxidase of purified antibody to C20orf20 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to C20orf20 on HeLa cell. [antibody concentration 10ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to C20orf20 on HeLa cell. [antibody concentration 10ug/ml].)
NCBI and Uniprot Product Information
Uniprot Description
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Subunit structure: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX. Ref.4
Subcellular location: Nucleus.
Sequence similarities: Belongs to the EAF7 family.
Research Articles on MRGBP
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Product Notes
The MRGBP mrgbp (Catalog #AAA648189) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MRGBP (C20orf20, MRG-binding Protein, MRG/MORF4L-binding Protein, FLJ10914) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MRGBP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Dilution: Immunofluorescence: 10ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml. Researchers should empirically determine the suitability of the MRGBP mrgbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK RRRT. It is sometimes possible for the material contained within the vial of "MRGBP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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