Goat anti-Mouse Fbn2 Polyclonal Antibody | anti-FBN2 antibody

Fbn2 (Fibrillin-2, Fbn-2)

Cat. Num. AAA647086

• Gene Names: FBN2; CCA; DA9
• Reactivity: Mouse
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Fbn2; Polyclonal Antibody; Fbn2 (Fibrillin-2; Fbn-2); Anti -Fbn2 (Fibrillin-2; anti-FBN2 antibody

• Host: Goat
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: Recognizes Fbn2. Species sequence homology: Mouse.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-FBN2 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:2000
• Immunogen: Synthetic peptide corresponding to C-KELRKLEEHNEDD, from Fbn2, at the internal region (near C-terminal) of the protein (NP_034311.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-FBN2 antibody

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Product Categories/Family for anti-FBN2 antibody

Antibodies; Abs to Fibrillin

NCBI and Uniprot Product Information

• NCBI GI #: 66346695
• NCBI GeneID: 2201
• NCBI Accession #: NP_001990.2
• NCBI GenBank Nucleotide #: NM_001999.3
• UniProt Accession #: P35556; Q59ES6; B4DU01
• Molecular Weight: 314,775 Da
• NCBI Official Full Name: fibrillin-2
• NCBI Official Synonym Full Names: fibrillin 2
• NCBI Official Symbol: FBN2
• NCBI Official Synonym Symbols: CCA; DA9
• NCBI Protein Information: fibrillin-2; fibrillin 5
• UniProt Protein Name: Fibrillin-2
• Protein Family: Fibrillin
• UniProt Gene Name: FBN2
• UniProt Entry Name: FBN2_HUMAN

NCBI Description

The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively

By similarity.

Subcellular location: Secreted › extracellular space › extracellular matrix.

Involvement in disease: Arthrogryposis, distal, 9 (DA9) [MIM:121050]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA9 is a connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12

Sequence similarities: Belongs to the fibrillin family.Contains 47 EGF-like domains.Contains 9 TB (TGF-beta binding) domains.