Mouse anti-Human C20orf7 Monoclonal Antibody | anti-NDUFAF5 antibody

C20orf7 (NADH Dehydrogenase [Ubiquinone] 1 alpha Subcomplex Assembly Factor 5, Probable Methyltransferase C20orf7, Mitochondrial, NDUFAF5, FLJ22324, MGC90272)

Cat. Num. AAA646890

• Gene Names: NDUFAF5; C20orf7; dJ842G6.1; bA526K24.2
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: C20orf7; Monoclonal Antibody; C20orf7 (NADH Dehydrogenase [Ubiquinone] 1 alpha Subcomplex Assembly Factor 5; Probable Methyltransferase C20orf7; Mitochondrial; NDUFAF5; FLJ22324; MGC90272); Anti -C20orf7 (NADH Dehydrogenase [Ubiquinone] 1 alpha Subcomplex Assembly Factor 5; anti-NDUFAF5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: 4A9
• Specificity: Recognizes human C20orf7.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCAWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPPGKKSQ

• Applicable Applications for anti-NDUFAF5 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Full length recombinant corresponding to aa1-159 from human C20orf7 (AAH05984) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-NDUFAF5 antibody

The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-NDUFAF5 antibody

Antibodies; Abs to Enzymes; Methyltransferase

NCBI and Uniprot Product Information

• NCBI GI #: 13543669
• NCBI GeneID: 79133
• UniProt Accession #: Q5TEU4; Q6GPH3; Q9H6F4; A8K166
• Molecular Weight: 38,918 Da
• NCBI Official Full Name: C20orf7 protein
• NCBI Official Synonym Full Names: NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
• NCBI Official Symbol: NDUFAF5
• NCBI Official Synonym Symbols: C20orf7; dJ842G6.1; bA526K24.2
• NCBI Protein Information: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; probable methyltransferase C20orf7, mitochondrial
• UniProt Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5
• Protein Family: Arginine-hydroxylase
• UniProt Gene Name: NDUFAF5
• UniProt Synonym Gene Names: C20orf7
• UniProt Entry Name: NDUF5_HUMAN

NCBI Description

The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

Function: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May have methyltransferase activity. Ref.5

Subcellular location: Mitochondrion inner membrane. Note: Peripherally localized on the matrix face of the mitochondrial inner membrane. Ref.5

Involvement in disease: Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities: Belongs to the methyltransferase superfamily.