Rabbit anti-Human, Mouse AKR7A2 Polyclonal Antibody | anti-AKR7A2 antibody
AKR7A2, NT (Aflatoxin B1 Aldehyde Reductase Member 2, Succinic Semialdehyde Reductase, SSA Reductase, AFB1 Aldehyde Reductase 1, AFB1-AR 1, Aldoketoreductase 7, AFAR, AFAR1, AKR7) (PE)
ELISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of anti-AKR7A2 antibody (N-term) in 293 cell line lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab. Western blot analysis of anti-AKR7A2 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Description
AKR7A2: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein type: Oxidoreductase; EC 1.1.1.n11
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: Golgi apparatus; mitochondrion; cytosol
Molecular Function: electron carrier activity; aldehyde reductase activity; phenanthrene-9,10-epoxide hydrolase activity
Biological Process: xenobiotic metabolic process; carbohydrate metabolic process; aldehyde metabolic process