Rabbit anti-Human NEURL2 Polyclonal Antibody | anti-NEURL2 antibody

NEURL2 (Neuralized-like Protein 2, NEURL2, C20orf163) (PE)

Cat. Num. AAA6457613

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified
• Synonyms: NEURL2; Polyclonal Antibody; NEURL2 (Neuralized-like Protein 2; C20orf163) (PE); anti-NEURL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NEURL2. Species Crossreactivity: human
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-NEURL2 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to human NEURL2.
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-NEURL2 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

References

Ota T., et al. Nat. Genet. 36:40-45(2004). Frigimelica E., et al. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. Deloukas P., et al. Nature 414:865-871(2001). Nastasi T., et al. Dev. Cell 6:269-282(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 33301415
• UniProt Accession #: Q9BR09; Q3KR34
• Molecular Weight: 31,690 Da
• NCBI Official Full Name: Neuralized-like protein 2
• UniProt Protein Name: Neuralized-like protein 2
• Protein Family: Neuralized-like protein
• UniProt Gene Name: NEURL2
• UniProt Synonym Gene Names: C20orf163
• UniProt Entry Name: NEUL2_HUMAN

NCBI Description

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

NEURL2: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

Protein type: Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: muscle tendon junction; VCB complex

Biological Process: protein ubiquitination; sarcomere organization