Rabbit anti-Human, Mouse CRYZ Polyclonal Antibody | anti-CRYZ antibody

CRYZ (Quinone Oxidoreductase, NADPH:quinone Reductase, Zeta-crystallin, CRYZ) (APC)

Cat. Num. AAA6455272

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CRYZ; Polyclonal Antibody; CRYZ (Quinone Oxidoreductase; NADPH:quinone Reductase; Zeta-crystallin; CRYZ) (APC); anti-CRYZ antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes CRYZ. Species Crossreactivity: human, mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CRYZ antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa248-282 at the C-terminal region of human CRYZ.
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-CRYZ antibody

Antibodies; Crystallins

References

Gonzalez P., et al. Biochem. Biophys. Res. Commun. 191:902-907(1993). Gonzalez P., et al. Genomics 21:317-324(1994). Ota T., et al. Nat. Genet. 36:40-45(2004). Suzuki Y., et al. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. Bechtel S., et al. BMC Genomics 8:399-399(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 194239674
• NCBI GeneID: 1429
• NCBI Accession #: NP_001123514
• NCBI GenBank Nucleotide #: NM_001130042.1
• UniProt Accession #: Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9; A6NN60; D3DQ76
• Molecular Weight: 37.6 kDa (352aa) confirmed by MALDI-TOF
• NCBI Official Full Name: quinone oxidoreductase isoform a
• NCBI Official Synonym Full Names: crystallin zeta
• NCBI Official Symbol: CRYZ
• NCBI Protein Information: quinone oxidoreductase
• UniProt Protein Name: Quinone oxidoreductase
• Protein Family: Zeta-crystallin
• UniProt Gene Name: CRYZ

NCBI Description

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Uniprot Description

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.