Western Blot (WB)
(RABGEF1 polyclonal antibody. Western Blot analysis of RABGEF1 expression in human liver.)
Mouse anti-Human RABGEF1 Polyclonal Antibody | anti-Rabgef1 antibody
RABGEF1 (Rab5 GDP/GTP Exchange Factor, Rabaptin-5-associated Exchange Factor for Rab5, RABEX5, Rabex-5, RAP1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(RABGEF1 polyclonal antibody. Western Blot analysis of RABGEF1 expression in human liver.)
Western Blot (WB)
(RABGEF1 polyclonal antibody. Western Blot analysis of RABGEF1 expression in human liver.)
Western Blot (WB)
(Western Blot analysis of RABGEF1 expression in transfected 293T cell line by RABGEF1 polyclonal antibody. Lane 1: RABGEF1 transfected lysate (54.01kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of RABGEF1 expression in transfected 293T cell line by RABGEF1 polyclonal antibody. Lane 1: RABGEF1 transfected lysate (54.01kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
Uniprot Description
RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rab; Motility/polarity/chemotaxis
Cellular Component: early endosome; cytoplasm; endosome; vesicle
Molecular Function: protein binding; DNA binding; zinc ion binding; metal ion binding; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding
Biological Process: negative regulation of mast cell activation; protein transport; negative regulation of protein amino acid phosphorylation; transport; negative regulation of inflammatory response; negative regulation of mast cell degranulation; negative regulation of Ras protein signal transduction; protein ubiquitination; endocytosis; negative regulation of receptor-mediated endocytosis; protein targeting to membrane; negative regulation of leukocyte migration
Research Articles on Rabgef1
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Product Notes
The Rabgef1 rabgef1 (Catalog #AAA642059) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The RABGEF1 (Rab5 GDP/GTP Exchange Factor, Rabaptin-5-associated Exchange Factor for Rab5, RABEX5, Rabex-5, RAP1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RABGEF1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the Rabgef1 rabgef1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL PPPLQPQVYA G. It is sometimes possible for the material contained within the vial of "RABGEF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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