Rabbit anti-Human GLB1 Polyclonal Antibody | anti-GLB1 antibody

GLB1, NT (GLB1, ELNR1, Beta-galactosidase, Acid beta-galactosidase, Elastin receptor 1)

Cat. Num. AAA641604

• Gene Names: GLB1; GLNB1 homolog; PII; PII PROTEIN; T7B11.16; T7B11_16
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: GLB1; Polyclonal Antibody; NT (GLB1; ELNR1; Beta-galactosidase; Acid beta-galactosidase; Elastin receptor 1); Anti -GLB1; anti-GLB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-GLB1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: GLB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the N-terminal region of human GLB1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GLB1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GLB1 antibody detected the GLB1 protein (arrow).)

Related Product Information for anti-GLB1 antibody

This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-GLB1 antibody

Antibodies; Abs to Elastin

NCBI and Uniprot Product Information

• NCBI GI #: 15234360
• NCBI GeneID: 828213
• NCBI Accession #: NP_192099.1
• NCBI GenBank Nucleotide #: NM_116421.3
• UniProt Accession #: Q9ZST4
• Molecular Weight: 21,275 Da
• NCBI Official Full Name: GLNB1-like protein
• NCBI Official Symbol: GLB1
• NCBI Official Synonym Symbols: GLNB1 homolog; PII; PII PROTEIN; T7B11.16; T7B11_16
• NCBI Protein Information: GLNB1-like protein
• UniProt Protein Name: Nitrogen regulatory protein P-II homolog
• Protein Family: Globulin
• UniProt Gene Name: GLB1
• UniProt Synonym Gene Names: GLNB1
• UniProt Entry Name: GLNB_ARATH

NCBI Description

encodes a PII protein that may function as part of a signal transduction network involved in perceiving the status of carbon and organic nitrogen. Forms a protein complex with N-acetylglutamate kinase and regulates the kinase activity by relieving the feedback inhibition of the kinase by arginine. Regulates acetyl-CoA carboxylase activity.

Uniprot Description

Function: Participates in sensing carbon and organic nitrogen status and regulates some steps of primary carbon and nitrogen metabolism. Required for nitrite uptake in chloroplasts and regulates arginine biosynthesis through interaction with acetylglutamate kinase (NAGK) in chloroplasts. Regulates fatty acids synthesis in chloroplasts by interacting with the acetyl-CoA carboxylase complex and inhibiting acetyl-CoA carboxylase (ACCase) activity. Ref.1 Ref.6 Ref.8

Subunit structure: Homodimer. Interacts with NAGK. Interaction with NAGK is dependent of MgATP and inhibited by 2-oxoglutarate, arginine, glutamate, citrate, and oxaloacetate. Ref.7 Ref.10

Subcellular location: Plastid › chloroplast Ref.1 Ref.7.

Induction: By light and sucrose. Down-regulated by treatment with amino acids. Ref.1

Disruption phenotype: No visible phenotype under normal growth condition, but increased sensitivity to elevated levels of nitrite. Ref.6

Sequence similarities: Belongs to the P(II) protein family.