Rabbit anti-Human Sulfatase 1 Polyclonal Antibody | anti-SULF1 antibody

Sulfatase 1 (SULF1, SULF-1, hSulf-1, Extracellular Sulfatase Sulf-1, KIAA1077) (Biotin)

Cat. Num. AAA6395611

• Gene Names: SULF1; SULF-1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Sulfatase 1; Polyclonal Antibody; Sulfatase 1 (SULF1; SULF-1; hSulf-1; Extracellular Sulfatase Sulf-1; KIAA1077) (Biotin); EC=3.1.6.-; anti-SULF1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SULF1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 5710

• Applicable Applications for anti-SULF1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SULF1, aa1-871 (NP_055985.1).
• Immunogen Sequence: MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SULF1 expression in transfected 293T cell line by SULF1 polyclonal antibody. Lane 1: SULF1 transfected lysate (101kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-SULF1 antibody

Antibodies; Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 189571635
• NCBI GeneID: 23213
• NCBI Accession #: NM_015170.2
• NCBI GenBank Nucleotide #: NM_015170
• UniProt Accession #: Q8IWU6
• NCBI Official Full Name: Homo sapiens sulfatase 1 (SULF1), transcript variant 3, mRNA
• NCBI Official Synonym Full Names: sulfatase 1
• NCBI Official Symbol: SULF1
• NCBI Official Synonym Symbols: SULF-1
• NCBI Protein Information: extracellular sulfatase Sulf-1
• UniProt Protein Name: Extracellular sulfatase Sulf-1
• Protein Family: Extracellular sulfatase
• UniProt Gene Name: SULF1
• UniProt Synonym Gene Names: KIAA1077; hSulf-1

NCBI Description

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.