Rabbit anti-Human NR2E1 Polyclonal Antibody | anti-NR2E1 antibody

NR2E1 (Nuclear Receptor Subfamily 2 Group E Member 1, Nuclear Receptor TLX, Protein Tailless Homolog, Tll, hTll, TLX) (Biotin)

Cat. Num. AAA6387449

• Gene Names: NR2E1; TLL; TLX; XTLL
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NR2E1; Polyclonal Antibody; NR2E1 (Nuclear Receptor Subfamily 2 Group E Member 1; Nuclear Receptor TLX; Protein Tailless Homolog; Tll; hTll; TLX) (Biotin); anti-NR2E1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NR2E1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-NR2E1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human NR2E1, aa1-385 (NP_003260.1).
• Immunogen Sequence: MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of NR2E1 expression in transfected 293T cell line by NR2E1 polyclonal antibody. Lane 1: NR2E1 transfected lysate (42.6kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-NR2E1 antibody

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells.

Product Categories/Family for anti-NR2E1 antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4507537
• NCBI GeneID: 7101
• NCBI Accession #: NP_003260.1
• NCBI GenBank Nucleotide #: NM_003269.2
• UniProt Accession #: Q9Y466; Q6ZMP8
• Molecular Weight: 46,400 Da
• NCBI Official Full Name: nuclear receptor subfamily 2 group E member 1 isoform b
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2, group E, member 1
• NCBI Official Symbol: NR2E1
• NCBI Official Synonym Symbols: TLL; TLX; XTLL
• NCBI Protein Information: nuclear receptor subfamily 2 group E member 1; tailless homolog; nuclear receptor TLX; tailes-related receptor; protein tailless homolog
• UniProt Protein Name: Nuclear receptor subfamily 2 group E member 1
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: NR2E1
• UniProt Synonym Gene Names: TLX; Tll; hTll
• UniProt Entry Name: NR2E1_HUMAN

NCBI Description

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Description

NR2E1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm

Molecular Function: zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity

Biological Process: extracellular matrix organization and biogenesis; behavioral fear response; somatic stem cell maintenance; regulation of dendrite morphogenesis; regulation of timing of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; amygdala development; cerebral cortex neuron differentiation; visual perception; layer formation in the cerebral cortex; nervous system development; transcription initiation from RNA polymerase II promoter; dentate gyrus development; cell fate commitment; generation of neurons in the forebrain; olfactory bulb development; positive regulation of cell cycle; social behavior; negative regulation of neuron differentiation; positive regulation of angiogenesis; anterior commissure morphogenesis; retina development in camera-type eye; negative regulation of astrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis