Rabbit anti-Human LHX4 Polyclonal Antibody | anti-LHX4 antibody

LHX4 (LIM/Homeobox Protein Lhx4, LIM Homeobox Protein 4) APC

Cat. Num. AAA6384181

• Gene Names: LHX4; CPHD4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LHX4; Polyclonal Antibody; LHX4 (LIM/Homeobox Protein Lhx4; LIM Homeobox Protein 4) APC; anti-LHX4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human LHX4.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-LHX4 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human LHX4, aa1-390 (NP_203129.1).
• Immunogen Sequence: MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(LHX4 rabbit polyclonal antibody. Western Blot analysis of LHX4 expression in human liver.)

Western Blot (WB)

(Western Blot analysis of LHX4 expression in transfected 293T cell line by LHX4 polyclonal antibody. Lane 1: LHX4 transfected lysate (43.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-LHX4 antibody

May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.

Product Categories/Family for anti-LHX4 antibody

Antibodies; Transcription Factors; Homeobox (HOX)

NCBI and Uniprot Product Information

• NCBI GI #: 15375314
• NCBI GeneID: 89884
• NCBI Accession #: NP_203129.1
• NCBI GenBank Nucleotide #: NM_033343.2
• UniProt Accession #: Q969G2; Q8NHE0; Q8NHM1; Q8TCJ1; Q8WWX2; Q969W2
• Molecular Weight: 43,124 Da
• NCBI Official Full Name: LIM/homeobox protein Lhx4
• NCBI Official Synonym Full Names: LIM homeobox 4
• NCBI Official Symbol: LHX4
• NCBI Official Synonym Symbols: CPHD4
• NCBI Protein Information: LIM/homeobox protein Lhx4; LIM homeobox protein 4
• UniProt Protein Name: LIM/homeobox protein Lhx4
• Protein Family: LIM/homeobox protein
• UniProt Gene Name: LHX4
• UniProt Synonym Gene Names: LIM homeobox protein 4
• UniProt Entry Name: LHX4_HUMAN

NCBI Description

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]

Uniprot Description

LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: nucleus

Molecular Function: zinc ion binding; sequence-specific DNA binding

Biological Process: organ morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; medial motor column neuron differentiation; motor axon guidance; negative regulation of apoptosis; placenta development

Disease: Pituitary Hormone Deficiency, Combined, 4