Zinc-alpha-2-glycoprotein Active Protein | AZGP1 active protein

Zinc-alpha-2-glycoprotein, Recombinant, Human (ZAG, ZA2G, AZGP1, Zn-alpha-2-glycoprotein, Zn-alpha-2-GP, ZNGP1)

Cat. Num. AAA637863

• Gene Names: AZGP1; ZAG; ZA2G
• Purity: Highly Purified; ~95% (RP-HPLC and SDS-PAGE)
• Synonyms: Zinc-alpha-2-glycoprotein; Recombinant; Human (ZAG; ZA2G; AZGP1; Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; ZNGP1); AZGP1 active protein

• Purity/Purification: Highly Purified; ~95% (RP-HPLC and SDS-PAGE)
• Form/Format: Supplied as a liquid in 20mM Tris, pH 8.0, 0.1mM DTT, 10% glycerol.
• Sequence: Gly-Ile-Thr-Ile-Pro

• Biological Activity: he ED50 as determined by the dose-dependant induction of IL-6 in primary human foreskin fibroblasts was found to be 2ng/ml, corresponding to a specific activity of 5x105units/mg.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.human

Related Product Information for AZGP1 active protein

Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum, sweat, and seminal and breast cyst fluids. It is identical in aa sequence to tumor-derived lipid mobilizing factor (LMF), a protein associated with the dramatic loss of adipose body stores in cancer cachexia, and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may be useful for the study of Diabetes and Obesity.

Product Categories/Family for AZGP1 active protein

Molecular Biology; MB-Carbohydrates; Glycoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 4502337
• NCBI GeneID: 563
• NCBI Accession #: NP_001176.1
• NCBI GenBank Nucleotide #: NM_001185.3
• UniProt Accession #: P25311; O60386; Q5XKQ4; Q8N4N0; D6W5T8
• Molecular Weight: ~30.25kD
• NCBI Official Full Name: zinc-alpha-2-glycoprotein
• NCBI Official Synonym Full Names: alpha-2-glycoprotein 1, zinc-binding
• NCBI Official Symbol: AZGP1
• NCBI Official Synonym Symbols: ZAG; ZA2G
• NCBI Protein Information: zinc-alpha-2-glycoprotein; zn-alpha-2-GP; Zn-alpha2-glycoprotein; zn-alpha-2-glycoprotein; Alpha-2-glycoprotein, zinc
• UniProt Protein Name: Zinc-alpha-2-glycoprotein
• Protein Family: Zinc-alpha-2-glycoprotein
• UniProt Gene Name: AZGP1
• UniProt Synonym Gene Names: ZAG; ZNGP1; Zn-alpha-2-GP
• UniProt Entry Name: ZA2G_HUMAN

Uniprot Description

AZGP1: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids. Belongs to the MHC class I family.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular space; plasma membrane; extracellular region; MHC class I protein complex; nucleus

Molecular Function: peptide antigen binding; protein transmembrane transporter activity; glycoprotein binding; antigen binding; ribonuclease activity

Biological Process: negative regulation of cell proliferation; antigen processing and presentation; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; immune response; detection of chemical stimulus involved in sensory perception of bitter taste; cell adhesion