ST2:Fc Active Protein
ST2:Fc, Recombinant, Human (Interleukin-1 Receptor-like 1, IL-1 Receptor-like 1, IL1RL1, IL-33 Receptor, Interleukin-33 Receptor)
Purity
Highly Purified>90% (SDS-PAGE)
Synonyms
ST2:Fc; Recombinant; Human (Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; IL-33 Receptor; Interleukin-33 Receptor); ST2:Fc active protein
Host
Human, HEK 293 cells
Specificity
Binds to human IL-33.
Purity/Purification
Highly Purified
>90% (SDS-PAGE)
>90% (SDS-PAGE)
Form/Format
Supplied as a 0.2um-filtered solution in PBS, pH 7.2.
Sequence
Signal peptide and the sequence of isoform 2 of human ST2 (aa 1-328) are fused at the C-terminus to the Fc portion of human IgG1.
Biological Activity
Interacts with human IL-33.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Working aliquots are stable for up to 3 months when stored at -20 degree C.
Long-term Storage: -20 degree C
Working aliquots are stable for up to 3 months when stored at -20 degree C.
Related Product Information for ST2:Fc active protein
The ST2 (Interleukin-1 receptor-like 1; Interleukin-33 receptor) gene was originally identified as a gene induced by serum or oncogene expression in fibroblasts. The gene produces a shorter soluble secreted form (ST2) and a longer, transmembrane form (ST2L) by alternative splicing. Soluble ST2 has been shown to downregulate the expression of TLR1 and TLR4. ST2L negatively regulates TLR4 signaling and induces endotoxin tolerance, and enhances Th2 responses. IL-33 is the specific ligand for ST2L.
Product Categories/Family for ST2:Fc active protein
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Product Notes
The ST2:Fc (Catalog #AAA636619) is an Active Protein produced from Human, HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Signal peptide and the sequence of isoform 2 of human ST2 (aa 1-328) are fused at the C-terminus to the Fc portion of human IgG1. It is sometimes possible for the material contained within the vial of "ST2:Fc, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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