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Aha1 Protein, active Recombinant Protein | HA1 recombinant protein

Aha1 Protein, active, Recombinant, Mouse (Activator of 90kD Heat Shock Protein ATPase Homolog 1, Ahsa1)

Gene Names
HA1; AHA1; F19F24.16; F19F24_16; H(+)-ATPase 1; HA1; OPEN STOMATA 2; OST2; PLASMA MEMBRANE PROTON ATPASE; PMA
Applications
Western Blot
Purity
Purified
~90% (SDS-PAGE)
Synonyms
Aha1 Protein; active; Recombinant; Mouse (Activator of 90kD Heat Shock Protein ATPase Homolog 1; Ahsa1); HA1 recombinant protein
Ordering
For Research Use Only!
Purity/Purification
Purified
~90% (SDS-PAGE)
Form/Format
Supplied as a liquid in 25mM Hepes, pH 7.2, 100mM potassium acetate, 50% glycerol.
Applicable Applications for HA1 recombinant protein
Western Blot (WB)
Application Notes
Suitable for use Western Blot.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for HA1 recombinant protein
Aha1 is a member of the Hsp90 cochaperone family, and is thought to stimulate Hsp90 ATPase activity by competing with p23 and other co-chaperones for Hsp90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/Hsp90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Product Categories/Family for HA1 recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
104,224 Da
NCBI Official Full Name
ATPase 1, plasma membrane-type
NCBI Official Symbol
HA1
NCBI Official Synonym Symbols
AHA1; F19F24.16; F19F24_16; H(+)-ATPase 1; HA1; OPEN STOMATA 2; OST2; PLASMA MEMBRANE PROTON ATPASE; PMA
NCBI Protein Information
H(+)-ATPase 1
UniProt Protein Name
ATPase 1, plasma membrane-type
UniProt Gene Name
AHA1
UniProt Entry Name
PMA1_ARATH

NCBI Description

Encodes a plasma membrane proton ATPase. Mutants have a reduced ability to close their stomata in response to drought and are affected in stomatal but not seed responsiveness to ABA.

Uniprot Description

Function: The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activity: ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Subunit structure: Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-948. Binding to 14-3-3 proteins activates the H+-ATPase

By similarity. Interacts with PPI1; this interaction promotes ATPase activity. Ref.5 Ref.7

Subcellular location: Cell membrane; Multi-pass membrane protein

Probable.

Post-translational modification: Phosphorylation level varies significantly during early response to general elicitors.

Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Research Articles on HA1

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Product Notes

The HA1 aha1 (Catalog #AAA636365) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Aha1 Protein, active can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use Western Blot. Researchers should empirically determine the suitability of the HA1 aha1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Aha1 Protein, active, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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