DNER active protein
DNER (extracellular domain):Fc, Recombinant, Human (BET, UNQ262/PRO299, Delta and Notch-like Epidermal Growth Factor-related Receptor)
Gene Names
DNER; bet; UNQ26
Purity
Highly Purified>95% (SDS-PAGE)
Synonyms
DNER; DNER (extracellular domain):Fc; Recombinant; Human (BET; UNQ262/PRO299; Delta and Notch-like Epidermal Growth Factor-related Receptor); DNER active protein
Host
Human, HEK 293 cells
Purity/Purification
Highly Purified
>95% (SDS-PAGE)
>95% (SDS-PAGE)
Form/Format
Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Sequence
Signal peptide and extracellular domain of human DNER (aa 1-637) are fused at the C-terminus to the Fc portion of human IgG1.
Biological Activity
Inhibits adipogenesis of 3T3L-1 cells.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Working aliquots are stable for up to 3 months when stored at -20 degree C.
Long-term Storage: -20 degree C
Working aliquots are stable for up to 3 months when stored at -20 degree C.
Related Product Information for DNER active protein
DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
Product Categories/Family for DNER active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~120kD (SDS-PAGE)
NCBI Official Full Name
delta and Notch-like epidermal growth factor-related receptor
NCBI Official Synonym Full Names
delta/notch-like EGF repeat containing
NCBI Official Symbol
DNER
NCBI Official Synonym Symbols
bet; UNQ26
NCBI Protein Information
delta and Notch-like epidermal growth factor-related receptor; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane
UniProt Protein Name
Delta and Notch-like epidermal growth factor-related receptor
UniProt Gene Name
DNER
UniProt Synonym Gene Names
BET
UniProt Entry Name
DNER_HUMAN
Uniprot Description
DNER: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q36.3
Cellular Component: cell soma; early endosome; dendrite; plasma membrane; integral to membrane
Molecular Function: clathrin binding; protein binding; transmembrane receptor activity; calcium ion binding; Notch binding
Biological Process: Notch signaling pathway; glial cell differentiation; central nervous system development; synaptogenesis; neuron migration; skeletal muscle fiber development; Notch receptor processing; endocytosis
Research Articles on DNER
Similar Products
Product Notes
The DNER dner (Catalog #AAA635991) is an Active Protein produced from Human, HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Signal peptide and extracellu lar domain of human DNER (aa 1-637) are fused at the C-terminus to the Fc portion of human IgG1. It is sometimes possible for the material contained within the vial of "DNER, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
