Hepatitis C Virus Core, Nucleocapsid p22 Recombinant Protein
Hepatitis C Virus Core, Nucleocapsid p22, Recombinant (HCV) (FITC)
Applications
ELISA, Western Blot
Purity
>=95% (SDS-PAGE with Coomassie staining). Chromatographically purified.
Synonyms
Hepatitis C Virus Core; Nucleocapsid p22; Recombinant (HCV) (FITC); Nucleocapsid p22 recombinant protein
Host
E Coli
Specificity
Immunoreactive with sera of HCV-infected individuals
Purity/Purification
>=95% (SDS-PAGE with Coomassie staining). Chromatographically purified.
Form/Format
Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 8mM urea, and 10mM b-ME. Labeled with FITC.
Applicable Applications for Hepatitis C Virus Core, Nucleocapsid p22 recombinant protein
ELISA (EIA), Western Blot (WB)
Application Notes
Recombinant HCV Core Antigen may be used in ELISA and Western Blot. Excellent for detection of HCV with minimal specificity problems.
Preparation and Storage
Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Hepatitis C Virus Core, Nucleocapsid p22 recombinant protein
The E.coli-derived recombinant protein contains the HCV core nucleocapsid immunodominant region, amino acids 2-192. This Fluorescein-labeled protein is fused with
beta-galactosidase (114 kDa) at the N-terminus.
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is co-translationally inserted into the membrane of the endoplasmic reticulum (ER). Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathway. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is co-translationally inserted into the membrane of the endoplasmic reticulum (ER). Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathway. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Product Categories/Family for Hepatitis C Virus Core, Nucleocapsid p22 recombinant protein
Similar Products
Product Notes
The Hepatitis C Virus Core, Nucleocapsid p22 (Catalog #AAA635828) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Hepatitis C Virus Core, Nucleocapsid p22 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Recombinant HCV Core Antigen may be used in ELISA and Western Blot. Excellent for detection of HCV with minimal specificity problems. Researchers should empirically determine the suitability of the Hepatitis C Virus Core, Nucleocapsid p22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hepatitis C Virus Core, Nucleocapsid p22, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
