Rabbit anti-Human RXFP2 Polyclonal Antibody | anti-RXFP2 antibody

RXFP2, CT (RXFP2, GPR106, GREAT, LGR8, Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2) (Azide free

Cat. Num. AAA6344528

• Gene Names: RXFP2; LGR8; GREAT; GPR106; INSL3R; LGR8.1; RXFPR2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RXFP2; Polyclonal Antibody; CT (RXFP2; GPR106; GREAT; LGR8; Relaxin receptor 2; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2) (Azide free; Relaxin family peptide receptor 2; anti-RXFP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-RXFP2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: RXFP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human RXFP2.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RXFP2 Antibody (C-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the RXFP2 antibody detected the RXFP2 protein (arrow).)

Related Product Information for anti-RXFP2 antibody

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-RXFP2 antibody

Antibodies; G Protein Receptors

References

Ars, E., et al. Int. J. Androl. (2010). In press: Ferlin, A., et al. Ann. N. Y. Acad. Sci. 1160, 215-218 (2009): Ferlin, A., et al. Ann. N. Y. Acad. Sci. 1160, 213-214 (2009): Feng, S., et al. Ann. N. Y. Acad. Sci. 1160, 197-204 (2009): Scott, D.J., et al. Ann. N. Y. Acad. Sci. 1160, 74-77 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 18677729
• NCBI GeneID: 122042
• NCBI Accession #: NP_570718.1
• NCBI GenBank Nucleotide #: NM_130806.3
• UniProt Accession #: Q8WXD0; Q3KU23; B1ALE9
• Molecular Weight: 86,453 Da
• NCBI Official Full Name: relaxin receptor 2 isoform 1
• NCBI Official Synonym Full Names: relaxin/insulin-like family peptide receptor 2
• NCBI Official Symbol: RXFP2
• NCBI Official Synonym Symbols: LGR8; GREAT; GPR106; INSL3R; LGR8.1; RXFPR2
• NCBI Protein Information: relaxin receptor 2; G-protein coupled receptor 106; relaxin family peptide receptor 2; G protein coupled receptor affecting testicular descent; G-protein coupled receptor affecting testicular descent; leucine-rich repeat-containing G protein-coupled recep
• UniProt Protein Name: Relaxin receptor 2
• Protein Family: Relaxin receptor
• UniProt Gene Name: RXFP2
• UniProt Synonym Gene Names: GPR106; GREAT; LGR8
• UniProt Entry Name: RXFP2_HUMAN

NCBI Description

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Description

LGR8: the relaxin receptor is a G-protein coupled receptor (GPCR) that leads to the stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: peptide hormone binding; protein-hormone receptor activity

Biological Process: negative regulation of cell proliferation; positive regulation of cAMP biosynthetic process; male gonad development; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, adenylate cyclase activating pathway; oocyte maturation; negative regulation of apoptosis

Disease: Cryptorchidism, Unilateral Or Bilateral