Mouse anti-Human Thioredoxin-1 Monoclonal Antibody | anti-trxA antibody
Thioredoxin-1 (Trx-1, trxA, fipA, tsnC, b3781, JW5856, Thioredoxin 1)
Gene Names
trxA; dasC; ECK3773; fipA; JW5856; tsnC
Reactivity
Human
Applications
ELISA, Immunoprecipitation
Purity
AscitesAscites
Synonyms
Thioredoxin-1; Monoclonal Antibody; Thioredoxin-1 (Trx-1; trxA; fipA; tsnC; b3781; JW5856; Thioredoxin 1); Anti -Thioredoxin-1 (Trx-1; anti-trxA antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
10K366
Specificity
Recognizes human Thioredoxin 1.
Purity/Purification
Ascites
Ascites
Ascites
Form/Format
Supplied as a liquid.
Applicable Applications for anti-trxA antibody
ELISA (EL/EIA), Immunoprecipitation (IP)
Application Notes
Suitable for use in ELISA and Immunoprecipitation.
Dilution: Immunoprecipitation: 1-2ul/400ul lysates
Dilution: Immunoprecipitation: 1-2ul/400ul lysates
Immunogen
Recombinant human protein purified from E.coli.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-trxA antibody
Thioredoxins (Trx) are small,multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/ dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds (1). Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations (2). Specific protein disulfide targets for reduction by Trx include protein disulfide -isomerase (PDI) (3) and a number of transcription factors such as p53 (4), NFkB (5) and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins (6-7).
Product Categories/Family for anti-trxA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
11,807 Da
NCBI Official Full Name
thioredoxin 1
NCBI Official Symbol
trxA
NCBI Official Synonym Symbols
dasC; ECK3773; fipA; JW5856; tsnC
NCBI Protein Information
thioredoxin 1
UniProt Protein Name
Thioredoxin-1
Protein Family
UniProt Gene Name
trxA
UniProt Synonym Gene Names
fipA; tsnC
UniProt Entry Name
THIO_ECOLI
NCBI Description
Thioredoxins are small electron-transfer proteins which contain a cysteine disulfide/dithiol active site. [More information is available at EcoCyc: EG11031].
Uniprot Description
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Subunit structure: Monomer. Interacts with bacteriophage T3 DNA polymerase.
Sequence similarities: Belongs to the thioredoxin family.Contains 1 thioredoxin domain.
Sequence caution: The sequence AAA24534.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAA67582.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on trxA
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Product Notes
The trxA trxa (Catalog #AAA633545) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Thioredoxin-1 (Trx-1, trxA, fipA, tsnC, b3781, JW5856, Thioredoxin 1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Thioredoxin-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunoprecipitation (IP). Suitable for use in ELISA and Immunoprecipitation. Dilution: Immunoprecipitation: 1-2ul/400ul lysates. Researchers should empirically determine the suitability of the trxA trxa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thioredoxin-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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