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Mouse anti-Human Phosphatase, Alkaline, Placental Monoclonal Antibody | anti-ALPP antibody

Phosphatase, Alkaline, Placental (PLAP, Alkaline Phosphatase Placental, Alkaline Phosphatase Placental Type, ALP, ALPP, Glycerophosphatase, PLAP-1, Regan Isozyme)

Gene Names
ALPP; ALP; PALP; PLAP; PLAP-1
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Immunofluorescence
Purity
Ascites
Mouse ascites
Synonyms
Phosphatase; Alkaline; Placental; Monoclonal Antibody; Placental (PLAP; Alkaline Phosphatase Placental; Alkaline Phosphatase Placental Type; ALP; ALPP; Glycerophosphatase; PLAP-1; Regan Isozyme); Anti -Phosphatase; anti-ALPP antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
9A329
Specificity
Human placental alkaline phosphatase, Regan and Nagao isoenzymes. No crossreaction with other isoenzymes of AP. Species Crossreactivity: Human.
Purity/Purification
Ascites
Mouse ascites
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Applicable Applications for anti-ALPP antibody
ELISA (EL/EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
Suitable for use in RID, Immunofluorescence, ELISA and Immunohistochemistry (Fr) (paraffin-embedded sections).
Immunogen
HEp-2 cells with boosted surface expression of PLAP.
Cellular Localization
Attached to the membrane by a GPI-anchor.
Positive Control
Placenta.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Product Categories/Family for anti-ALPP antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
250
UniProt Accession #
Molecular Weight
57,954 Da
NCBI Official Full Name
placental alkaline phosphatase
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Official Symbol
ALPP
NCBI Official Synonym Symbols
ALP; PALP; PLAP; PLAP-1
NCBI Protein Information
alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
UniProt Protein Name
Alkaline phosphatase, placental type
Protein Family
UniProt Gene Name
ALPP
UniProt Synonym Gene Names
PLAP; PLAP-1
UniProt Entry Name
PPB1_HUMAN

NCBI Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.1; Cell surface; Cofactor and Vitamin Metabolism - folate biosynthesis; Phosphatase (non-protein); Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: alkaline phosphatase activity; zinc ion binding; magnesium ion binding

Biological Process: dephosphorylation

Research Articles on ALPP

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Product Notes

The ALPP alpp (Catalog #AAA632603) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Phosphatase, Alkaline, Placental (PLAP, Alkaline Phosphatase Placental, Alkaline Phosphatase Placental Type, ALP, ALPP, Glycerophosphatase, PLAP-1, Regan Isozyme) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Phosphatase, Alkaline, Placental can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in RID, Immunofluorescence, ELISA and Immunohistochemistry (Fr) (paraffin-embedded sections). Researchers should empirically determine the suitability of the ALPP alpp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phosphatase, Alkaline, Placental, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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