Rabbit anti-Human MEOX1 Polyclonal Antibody | anti-MEOX1 antibody

MEOX1, ID (MEOX1, MOX1, Homeobox protein MOX-1, Mesenchyme homeobox 1) (APC)

Cat. Num. AAA6320222

• Gene Names: MEOX1; KFS2; MOX1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MEOX1; Polyclonal Antibody; ID (MEOX1; MOX1; Homeobox protein MOX-1; Mesenchyme homeobox 1) (APC); Mesenchyme homeobox 1; anti-MEOX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
• Sequence Length: 254

• Applicable Applications for anti-MEOX1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: MEOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-165 amino acids from the Central region of human MEOX1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(MEOX1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MEOX1 antibody detected the MEOX1 protein (arrow).)

Western Blot (WB)

(Western blot analysis of MEOX1 (arrow) using rabbit polyclonal MEOX1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MEOX1 gene.)

Immunohistochemistry (IHC)

(MEOX1 Antibody (Center) (AP14566c)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MEOX1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-MEOX1 antibody

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.

Product Categories/Family for anti-MEOX1 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

Vatanavicharn, N., et al. Am. J. Med. Genet. A 143A (19), 2292-2302 (2007): Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006). Gianakopoulos, P.J., et al. J. Biol. Chem. 280(22):21022-21028(2005). Petropoulos, H., et al. J. Biol. Chem. 279(23):23874-23881(2004). Stamataki, D., et al. FEBS Lett. 499(3):274-278(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 4758710
• NCBI GeneID: 4222
• NCBI Accession #: NP_004518.1; NP_001035091.1
• NCBI GenBank Nucleotide #: NP_004518.1
• UniProt Accession #: P50221
• NCBI Official Full Name: homeobox protein MOX-1 isoform 1
• NCBI Official Synonym Full Names: mesenchyme homeobox 1
• NCBI Official Symbol: MEOX1
• NCBI Official Synonym Symbols: KFS2; MOX1
• NCBI Protein Information: homeobox protein MOX-1
• UniProt Protein Name: Homeobox protein MOX-1
• Protein Family: Homeobox protein
• UniProt Gene Name: MEOX1
• UniProt Synonym Gene Names: MOX1
• UniProt Entry Name: MEOX1_HUMAN

NCBI Description

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

MEOX1: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: somite specification; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter

Disease: Klippel-feil Syndrome 2, Autosomal Recessive