Rabbit anti-Human USP6 Polyclonal Antibody | anti-USP6 antibody

USP6, NT (Ubiquitin Carboxyl-terminal Hydrolase 6, Ubiquitin Thiolesterase 6, Ubiquitin-specific-processing Protease 6, Deubiquitinating Enzyme 6, Proto-oncogene TRE-2, HRP1, TRE2)

Cat. Num. AAA631074

• Gene Names: USP6; HRP1; TRE2; TRE17; Tre-2; USP6-short
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: USP6; Polyclonal Antibody; NT (Ubiquitin Carboxyl-terminal Hydrolase 6; Ubiquitin Thiolesterase 6; Ubiquitin-specific-processing Protease 6; Deubiquitinating Enzyme 6; Proto-oncogene TRE-2; HRP1; TRE2); Anti -USP6; anti-USP6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human USP6.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-USP6 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the N-terminal region of human USP6 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-USP6 antibody

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Product Categories/Family for anti-USP6 antibody

Antibodies; Abs to Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 109638751
• NCBI GeneID: 9098
• NCBI Accession #: NP_004496.2
• NCBI GenBank Nucleotide #: NM_004505.2
• UniProt Accession #: P35125; Q15634; Q86WP6; Q8IWT4; Q15635; Q1K9C9; Q5EXX1; Q6U210; Q9UDD3
• Molecular Weight: 158,658 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 6
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 6 (Tre-2 oncogene)
• NCBI Official Symbol: USP6
• NCBI Official Synonym Symbols: HRP1; TRE2; TRE17; Tre-2; USP6-short
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 6; tre-2 oncogene; OTTHUMP00000125301; proto-oncogene TRE-2; hyperpolymorphic gene 1; ubiquitin thioesterase 6; deubiquitinating enzyme 6; ubiquitin thiolesterase 6; ubiquitin specific peptidase 6-; ubiquitin-specific protease USP6; ubiquitin-specific-processing protease 6; ubiquitin specific protease 6 (Tre-2 oncogene)
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 6
• Protein Family: USP6 N-terminal-like protein
• UniProt Gene Name: USP6
• UniProt Synonym Gene Names: HRP1; TRE2
• UniProt Entry Name: UBP6_HUMAN

Uniprot Description

USP6: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Ubiquitin-specific protease; Protease; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: recycling endosome; lysosome; cytoplasm; plasma membrane

Molecular Function: calmodulin binding; protein binding; nucleic acid binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein modification process