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Western Blot (WB) (IL1R1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IL1R1 antibody detected the IL1R1 protein (arrow).)

Rabbit anti-Human, Mouse IL1R1 Polyclonal Antibody | anti-IL1R1 antibody

IL1R1, CT (IL1R1, IL1R, IL1RA, IL1RT1, Interleukin-1 receptor type 1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, Interleukin-1 receptor type I, p80, CD121a, Interleukin-1 receptor type 1, membrane form, Interleukin-1 receptor type 1

Gene Names
IL1R1; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
Reactivity
Human, Mouse
Applications
Western Blot, ELISA
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
IL1R1; Polyclonal Antibody; CT (IL1R1; IL1R; IL1RA; IL1RT1; Interleukin-1 receptor type 1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; Interleukin-1 receptor type I; p80; CD121a; membrane form; soluble form; anti-IL1R1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Applicable Applications for anti-IL1R1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
IL1R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 421-450 amino acids from the C-terminal region of human IL1R1.
Conjugate
AP
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(IL1R1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IL1R1 antibody detected the IL1R1 protein (arrow).)

Western Blot (WB) (IL1R1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IL1R1 antibody detected the IL1R1 protein (arrow).)

Western Blot (WB)

(IL1R1 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the IL1R1 antibody detected the IL1R1 protein (arrow).)

Western Blot (WB) (IL1R1 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the IL1R1 antibody detected the IL1R1 protein (arrow).)
Related Product Information for anti-IL1R1 antibody
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Product Categories/Family for anti-IL1R1 antibody
References
Fragoso, J.M., et al. Immunol. Lett. 133(2):106-111(2010). Franchim, C.S., et al. Hypertens Pregnancy (2010). In press: Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010). de Wit, E., et al. Mamm. Genome (2010). In press: Ryckman, K.K., et al. PLoS ONE 5 (8), E12273 (2010).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
80kDa
NCBI Official Full Name
interleukin-1 receptor type 1
NCBI Official Synonym Full Names
interleukin 1 receptor, type I
NCBI Official Symbol
IL1R1
NCBI Official Synonym Symbols
P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
NCBI Protein Information
interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I
UniProt Protein Name
Interleukin-1 receptor type 1
Protein Family
UniProt Gene Name
IL1R1
UniProt Synonym Gene Names
IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI
UniProt Entry Name
IL1R1_HUMAN

Uniprot Description

IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: interleukin-1, Type I, activating receptor activity; protein binding; signal transducer activity; transmembrane receptor activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity

Biological Process: cell surface receptor linked signal transduction; regulation of inflammatory response; immune response

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Product Notes

The IL1R1 il1r1 (Catalog #AAA6310025) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL1R1, CT (IL1R1, IL1R, IL1RA, IL1RT1, Interleukin-1 receptor type 1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, Interleukin-1 receptor type I, p80, CD121a, Interleukin-1 receptor type 1, membrane form, Interleukin-1 receptor type 1 reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL1R1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the IL1R1 il1r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1R1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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