Rabbit anti-Human, Mouse FOXF1 Polyclonal Antibody | anti-FOXF1 antibody

FOXF1, NT (FOXF1, FKHL5, FREAC1, Forkhead box protein F1, Forkhead-related activator 1, Forkhead-related protein FKHL5, Forkhead-related transcription factor 1) (Biotin)

Cat. Num. AAA6299775

• Gene Names: FOXF1; FKHL5; ACDMPV; FREAC1
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FOXF1; Polyclonal Antibody; NT (FOXF1; FKHL5; FREAC1; Forkhead box protein F1; Forkhead-related activator 1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1) (Biotin); Forkhead-related transcription factor 1; anti-FOXF1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-FOXF1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FOXF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human FOXF1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FOXF1 Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the FOXF1 antibody detected the FOXF1 protein (arrow).)

Related Product Information for anti-FOXF1 antibody

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.

Product Categories/Family for anti-FOXF1 antibody

Antibodies; Transcription Factors

References

Saito, R.A., et al. Cancer Res. 70(7):2644-2654(2010). Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010). Nilsson, J., et al. Cancer Res. 70(5):2020-2029(2010). Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010). Shaw-Smith, C. Eur J Med Genet 53(1):6-13(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 110735445
• NCBI GeneID: 2294
• NCBI Accession #: NP_001442.2
• NCBI GenBank Nucleotide #: NM_001451.2
• UniProt Accession #: Q12946; Q5FWE5; B2RAF4
• Molecular Weight: 40,122 Da
• NCBI Official Full Name: forkhead box protein F1
• NCBI Official Synonym Full Names: forkhead box F1
• NCBI Official Symbol: FOXF1
• NCBI Official Synonym Symbols: FKHL5; ACDMPV; FREAC1
• NCBI Protein Information: forkhead box protein F1
• UniProt Protein Name: Forkhead box protein F1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXF1
• UniProt Synonym Gene Names: FKHL5; FREAC1; FREAC-1

NCBI Description

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

Uniprot Description

FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: nucleus; transcription factor complex

Molecular Function: DNA binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding

Biological Process: blood vessel development; embryonic digestive tract morphogenesis; embryonic ectodermal gut morphogenesis; gut development; heart development; in utero embryonic development; lung development; midgut development; morphogenesis of a branching structure; pancreas development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; respiratory tube development

Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins