Rabbit anti-Human, Mouse CDK6 Polyclonal Antibody | anti-CDK6 antibody

CDK6, phosphorylated (Tyr24) (Cell Division Protein Kinase 6, Serine/Threonine-protein Kinase PLSTIRE, Crk2, MGC59692)

Cat. Num. AAA629853

• Gene Names: CDK6; PLSTIRE; MGC59692
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CDK6; Polyclonal Antibody; phosphorylated (Tyr24) (Cell Division Protein Kinase 6; Serine/Threonine-protein Kinase PLSTIRE; Crk2; MGC59692); Anti -CDK6; anti-CDK6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human cdk6 when phosphorylated at tyrosine 24. Species Cross-Reactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-CDK6 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic phosphopeptide corresponding to human CDK6 around the phosphorylation site of tyrosine 24 (G-A-YP-G-K).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CDK6 antibody

Cyclin-dependent kinases (cdk) are the catalytic subunits of the cyclin/cdk complexes, which phosphorylate substrates on threonine/serine residues. Cdk6 associates with the D-type cyclins and is important in the progression of cells from the G1-phase to the S-phase of the cell cycle.

Product Categories/Family for anti-CDK6 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 223718134
• NCBI GeneID: 1021
• NCBI Accession #: NP_001138778.1
• NCBI GenBank Nucleotide #: NM_001145306.1
• UniProt Accession #: Q00534
• Molecular Weight: 36,938 Da
• NCBI Official Full Name: cyclin-dependent kinase 6
• NCBI Official Synonym Full Names: cyclin-dependent kinase 6
• NCBI Official Symbol: CDK6
• NCBI Official Synonym Symbols: PLSTIRE; MGC59692
• NCBI Protein Information: cyclin-dependent kinase 6; OTTHUMP00000162478; OTTHUMP00000208823; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE
• UniProt Protein Name: Cyclin-dependent kinase 6
• Protein Family: Cyclin-dependent kinase
• UniProt Gene Name: CDK6
• UniProt Entry Name: CDK6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

Uniprot Description

CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Protein kinase, CMGC; Cell cycle regulation; Kinase, protein; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: nucleoplasm; ruffle; centrosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus

Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding

Biological Process: Notch signaling pathway; negative regulation of myeloid cell differentiation; dentate gyrus development; response to virus; gliogenesis; T cell differentiation in the thymus; astrocyte development; protein amino acid phosphorylation; negative regulation of cell cycle; regulation of erythrocyte differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; negative regulation of cell differentiation; regulation of gene expression; cell division; generation of neurons; cell dedifferentiation; negative regulation of osteoblast differentiation; mitotic cell cycle; positive regulation of cell-matrix adhesion; cell cycle arrest; lateral ventricle development; G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation

Disease: Microcephaly 12, Primary, Autosomal Recessive