Rabbit anti-Human DCDC2 Polyclonal Antibody | anti-DCDC2 antibody

DCDC2, ID (DCDC2, KIAA1154, RU2, Doublecortin domain-containing protein 2, Protein RU2S) (PE)

Cat. Num. AAA6291056

• Gene Names: DCDC2; NSC; RU2; RU2S; DCDC2A; DFNB66; NPHP19
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DCDC2; Polyclonal Antibody; ID (DCDC2; KIAA1154; RU2; Doublecortin domain-containing protein 2; Protein RU2S) (PE); Protein RU2S; anti-DCDC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-DCDC2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: DCDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the Central region of human DCDC2.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(DCDC2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DCDC2 antibody detected the DCDC2 protein (arrow).)

Related Product Information for anti-DCDC2 antibody

This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Mutations in this gene have been associated with Reading Disability (RD), also referred to as developmental dyslexia.

Product Categories/Family for anti-DCDC2 antibody

Antibodies; KIAA; orf

References

Couto, J.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 447-462 (2010): Meda, S.A., et al. Neuroimage (2009). In press: Couto, J.M., et al. Biol. Psychiatry 66(4):368-375(2009). Wilcke, A., et al. Ann Dyslexia 59(1):1-11(2009). Meda, S.A., et al. Brain Imaging Behav 2(1):21-26(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 307219252
• NCBI GeneID: 51473
• NCBI Accession #: NP_001182539.1; NP_057440.2
• NCBI GenBank Nucleotide #: NM_001195610.1
• UniProt Accession #: Q9UHG0; Q5VTR8; Q5VTR9; Q86W35; Q9UFD1; Q9UHG1; Q9ULR6
• Molecular Weight: 25,582 Da
• NCBI Official Full Name: doublecortin domain-containing protein 2
• NCBI Official Synonym Full Names: doublecortin domain containing 2
• NCBI Official Symbol: DCDC2
• NCBI Official Synonym Symbols: NSC; RU2; RU2S; DCDC2A; DFNB66; NPHP19
• NCBI Protein Information: doublecortin domain-containing protein 2
• UniProt Protein Name: Doublecortin domain-containing protein 2
• Protein Family: Doublecortin domain-containing protein
• UniProt Gene Name: DCDC2
• UniProt Synonym Gene Names: KIAA1154; RU2
• UniProt Entry Name: DCDC2_HUMAN

NCBI Description

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]