Rabbit anti-Human CTSZ Polyclonal Antibody | anti-CTSZ antibody

CTSZ, NT (CTSZ, Cathepsin Z, Cathepsin P, Cathepsin X) (PE)

Cat. Num. AAA6289956

• Gene Names: CTSZ; CTSX
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CTSZ; Polyclonal Antibody; NT (CTSZ; Cathepsin Z; Cathepsin P; Cathepsin X) (PE); Cathepsin X; anti-CTSZ antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-CTSZ antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CTSZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human CTSZ.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CTSZ Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the CTSZ antibody detected the CTSZ protein (arrow).)

Related Product Information for anti-CTSZ antibody

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.

Product Categories/Family for anti-CTSZ antibody

Antibodies; Cathepsin

References

Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008). Cooke, G.S., et al. Am. J. Respir. Crit. Care Med. 178(2):203-207(2008). Harris, S.E., et al. BMC Genet. 8, 43 (2007): Lechner, A.M., et al. J. Biol. Chem. 281(51):39588-39597(2006). Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 22538442
• NCBI GeneID: 1522
• NCBI Accession #: NP_001327.2
• NCBI GenBank Nucleotide #: NM_001336.3
• UniProt Accession #: Q9UBR2; O75331; Q9UQV5; Q9UQV6; B2RC40
• Molecular Weight: 33,868 Da
• NCBI Official Full Name: cathepsin Z preproprotein
• NCBI Official Synonym Full Names: cathepsin Z
• NCBI Official Symbol: CTSZ
• NCBI Official Synonym Symbols: CTSX
• NCBI Protein Information: cathepsin Z; cathepsin P; cathepsin X; cathepsin Y; cathepsin B2; cathepsin IV; cathepsin Z1; preprocathepsin P; carboxypeptidase LB; lysosomal carboxypeptidase B; cysteine-type carboxypeptidase
• UniProt Protein Name: Cathepsin Z
• Protein Family: Cathepsin
• UniProt Gene Name: CTSZ
• UniProt Entry Name: CATZ_HUMAN

NCBI Description

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

Uniprot Description

CTSZ: Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. Belongs to the peptidase C1 family.

Protein type: EC 3.4.18.1; Protease

Chromosomal Location of Human Ortholog: 20q13.32

Cellular Component: extracellular space; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum; plasma membrane

Molecular Function: cysteine-type peptidase activity

Biological Process: cellular protein metabolic process; proteolysis; angiotensin maturation

Disease: Mycobacterium Tuberculosis, Susceptibility To