Immunocytochemistry (ICC)
(Immunocytochemistry of beta-COP in NIH-3T3 cells using MBS628742.)
Rabbit anti-Mouse, Rat COP, beta Polyclonal Antibody | anti-CARD16 antibody
COP, beta (Coatomer Protein beta)
Purified
Purified
Immunocytochemistry (ICC)
(Immunocytochemistry of beta-COP in NIH-3T3 cells using MBS628742.)
Immunocytochemistry (ICC)
(Immunocytochemistry of beta-COP in NIH-3T3 cells using MBS628742.)
NCBI and Uniprot Product Information
Uniprot Description
CARD16: Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Down-regulated in patients suffering of Huntington disease. Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2. 2 isoforms of the human protein are produced by alternative splicing
Chromosomal Location of Human Ortholog: 11q22
Molecular Function: cysteine protease inhibitor activity
Biological Process: regulation of apoptosis
Research Articles on CARD16
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Product Notes
The CARD16 card16 (Catalog #AAA628742) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COP, beta (Coatomer Protein beta) reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's COP, beta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Immunocytochemistry (1:2000), Immunohistochemistry (frozen sections), Western Blot (1:1000). Researchers should empirically determine the suitability of the CARD16 card16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COP, beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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