Rabbit anti-Human, Mouse CD79B Polyclonal Antibody | anti-CD79B antibody

CD79B, ID (CD79B, B29, IGB, B Cell antigen receptor complex-associated protein beta chain, B Cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b) (FITC)

Cat. Num. AAA6283492

• Gene Names: CD79B; B29; IGB; AGM6
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CD79B; Polyclonal Antibody; ID (CD79B; B29; IGB; B Cell antigen receptor complex-associated protein beta chain; B Cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD79b) (FITC); B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; CD79b; anti-CD79B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-CD79B antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CD79B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the Central region of human CD79B.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of CD79B (arrow) using rabbit polyclonal CD79B Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CD79B gene.)

Western Blot (WB)

(CD79B Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CD79B antibody detected the CD79B protein (arrow).)

Related Product Information for anti-CD79B antibody

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

Product Categories/Family for anti-CD79B antibody

Antibodies; CD Markers

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 90193592
• NCBI GeneID: 974
• NCBI Accession #: NP_001035022.1
• NCBI GenBank Nucleotide #: NM_001039933.1
• UniProt Accession #: P40259; Q53FS2; Q9BU06
• Molecular Weight: 26,119 Da
• NCBI Official Full Name: B-cell antigen receptor complex-associated protein beta chain isoform 3
• NCBI Official Synonym Full Names: CD79b molecule, immunoglobulin-associated beta
• NCBI Official Symbol: CD79B
• NCBI Official Synonym Symbols: B29; IGB; AGM6
• NCBI Protein Information: B-cell antigen receptor complex-associated protein beta chain
• UniProt Protein Name: B-cell antigen receptor complex-associated protein beta chain
• Protein Family: B-cell antigen receptor complex-associated protein
• UniProt Gene Name: CD79B
• UniProt Synonym Gene Names: B29; IGB
• UniProt Entry Name: CD79B_HUMAN

NCBI Description

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: B cell receptor signaling pathway; immune response; signal transduction

Disease: Agammaglobulinemia 6, Autosomal Recessive