Rabbit Serotonin Receptor 1D Polyclonal Antibody | anti-HTR1D antibody

Serotonin Receptor 1D (5-Hydroxytryptamine 1D Receptor, 5-Hydroxytryptamine Serotonin Receptor 1D, 5HT1D, 5-HT-1D, 5-HT-1D-alpha, G Protein Coupled Receptor 14, GPCR14, HT1DA, HTR1DA, HTRL, RDC4)

Cat. Num. AAA627667

• Gene Names: HTR1D; 5-HT-1D
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Serotonin Receptor 1D; Polyclonal Antibody; Serotonin Receptor 1D (5-Hydroxytryptamine 1D Receptor; 5-Hydroxytryptamine Serotonin Receptor 1D; 5HT1D; 5-HT-1D; 5-HT-1D-alpha; G Protein Coupled Receptor 14; GPCR14; HT1DA; HTR1DA; HTRL; RDC4); Anti -Serotonin Receptor 1D (5-Hydroxytryptamine 1D Receptor; anti-HTR1D antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: A 40kD band is detected. Species Crossreactivity: Human, Mouse, Rat
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

• Applicable Applications for anti-HTR1D antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: This antibody was generated by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 1-18 and 251-267 of rat 5-HT1DR (Genbank accession no. NP_036984) (7).
• Positive Control: human, mouse, or rat brain
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-HTR1D antibody

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1,2). The 5-HT1D (formerly known as 5-HT1Da) receptor has 63% overall structural homology with the 5-HT1B receptor and a 77% amino acid sequence homology in the seven transmembrane domains (3). In situ hybridization studies have detected highest level of mRNA in primary olfactory cortex, accumbens nucleus, caudate putamen, lateral mammilary nucleus and medial vestibular nucleus (4). The presence of relatively high levels of 5-HT1D mRNA in the locus coeruleus suggest that, when expressed on nerve terminals, this receptor could modulate the release of catecholamines. The 5-HT1D receptor may function as an autoreceptor. Like 5-HT1B receptors, 5-HT1D receptors also appear to act as heteroreceptors. Acting on the 5-HT1D receptors, 5-HT appears to inhibit release of glutamate from rat cerebellar synaptosomes and acetylcholine from guinea pig hippocampal synaptosomes (5). It has been suggested that neurogenic inflammation and nociceptive activity within trigemino- vascular afferents. Endothelium-dependent relaxation in the pig coronary artery has been claimed to be mediated by 5-HT1D receptors (6). Like other members of the 5-HT1 family, 5-HT1D receptors are negatively coupled to adenylate cyclase.

Product Categories/Family for anti-HTR1D antibody

Antibodies; Abs to Serotonin Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 1903314
• NCBI GeneID: 397309
• UniProt Accession #: P79400
• Molecular Weight: 32,669 Da
• NCBI Official Full Name: serotonin receptor 1D
• NCBI Official Symbol: HTR1D
• NCBI Official Synonym Symbols: 5-HT-1D
• NCBI Protein Information: 5-hydroxytryptamine receptor 1D; 5-HT1D receptor; serotonin receptor 1D
• UniProt Protein Name: 5-hydroxytryptamine receptor 1D
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR1D
• UniProt Entry Name: 5HT1D_PIG

Uniprot Description

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Subcellular location: Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.