Rabbit anti-Human ANP32A Polyclonal Antibody | anti-ANP32A antibody

ANP32A, ID (ANP32A, C15orf1, LANP, MAPM, PHAP1, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A,

Cat. Num. AAA6273830

• Gene Names: ANP32A; LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ANP32A; Polyclonal Antibody; ID (ANP32A; C15orf1; LANP; MAPM; PHAP1; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; ; Putative HLA-DR-associated protein I; anti-ANP32A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-ANP32A antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: ANP32A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the Central region of human ANP32A.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(ANP32A Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ANP32A antibody detected the ANP32A protein (arrow).)

Immunohistochemistry (IHC)

(ANP32A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ANP32A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-ANP32A antibody

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.

Product Categories/Family for anti-ANP32A antibody

Antibodies; HLA

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Habrukowich, C., et al. J. Biol. Chem. 285(35):26825-26831(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Valdes, A.M., et al. Arthritis Rheum. 60(7):2046-2054(2009). Matilla, A., et al. Cerebellum 4(1):7-18(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 5453880
• NCBI GeneID: 8125
• NCBI Accession #: NP_006296.1
• NCBI GenBank Nucleotide #: NM_006305.3
• UniProt Accession #: P39687; Q53FK4; Q5J8L8; Q7M4N6; B2R6T4
• Molecular Weight: 28,585 Da
• NCBI Official Full Name: acidic leucine-rich nuclear phosphoprotein 32 family member A
• NCBI Official Synonym Full Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
• NCBI Official Symbol: ANP32A
• NCBI Official Synonym Symbols: LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
• NCBI Protein Information: acidic leucine-rich nuclear phosphoprotein 32 family member A; acidic nuclear phosphoprotein pp32; cerebellar leucine rich acidic nuclear protein; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; leucine-rich acidic nuclear protein; mapmodulin; po
• UniProt Protein Name: Acidic leucine-rich nuclear phosphoprotein 32 family member A
• Protein Family: Acidic leucine-rich nuclear phosphoprotein 32 family
• UniProt Gene Name: ANP32A
• UniProt Synonym Gene Names: C15orf1; LANP; MAPM; PHAP1; pp32; LANP; PHAPI
• UniProt Entry Name: AN32A_HUMAN

Uniprot Description

ANP32A: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. Belongs to the ANP32 family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: nucleoplasm; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; gene expression; nucleocytoplasmic transport