Rabbit Rhes Polyclonal Antibody | anti-Rhes antibody
Rhes, CT (RASD2, GTP-binding Protein Rhes, Ras Homolog Enriched in Striatum, Tumor Endothelial Marker 2, TEM2) (HRP)
WB: 1:500 detects Rhes in human pancreas tissue lysate.
Applications are based on unconjugated antibody.
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
Uniprot Description
RASD2: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Belongs to the small GTPase superfamily. RasD family.
Protein type: G protein, monomeric, RasD; G protein, monomeric; G protein
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: plasma membrane
Molecular Function: GTPase activity; GTP binding; ubiquitin conjugating enzyme binding; G-protein beta-subunit binding
Biological Process: positive regulation of protein sumoylation; positive regulation of protein kinase B signaling cascade; synaptic transmission, dopaminergic; metabolic process; small GTPase mediated signal transduction; locomotory behavior; negative regulation of protein ubiquitination
Research Articles on Rhes
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Product Notes
The Rhes rasd2 (Catalog #AAA6270104) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rhes, CT (RASD2, GTP-binding Protein Rhes, Ras Homolog Enriched in Striatum, Tumor Endothelial Marker 2, TEM2) (HRP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Rhes can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P: 1:500 detects Rhes in paraffin-embedded human pancreas cells. WB: 1:500 detects Rhes in human pancreas tissue lysate. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the Rhes rasd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rhes, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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