Rabbit anti-Human Secretory Leukocyte Protease Inhibitor Polyclonal Antibody | anti-SLPI antibody

Secretory Leukocyte Protease Inhibitor (SLPI, ALK1, Antileukoproteinase, ALP, BLPI, HUSI, HUSI-1, HUSI-I, Mucus Proteinase Inhibitor, MPI, Protease Inhibitor WAP4, Secretory Leukocyte Peptidase Inhibitor, Seminal Proteinase Inhibitor, WAP4, WAP Four-Disul

Cat. Num. AAA625474

• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Secretory Leukocyte Protease Inhibitor; Polyclonal Antibody; Secretory Leukocyte Protease Inhibitor (SLPI; ALK1; Antileukoproteinase; ALP; BLPI; HUSI; HUSI-1; HUSI-I; Mucus Proteinase Inhibitor; MPI; Protease Inhibitor WAP4; Secretory Leukocyte Peptidase Inhibitor; Seminal Proteinase Inhibitor; WAP4; WAP Four-Disul; Anti -Secretory Leukocyte Protease Inhibitor (SLPI; anti-SLPI antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human secretory leukocyte proteinase inhibitor (SLPI).
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

• Applicable Applications for anti-SLPI antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.; Dilution: Western Blot: 1:10
• Immunogen: Human secretory leukocyte proteinase inhibitor (SLPI).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLPI antibody

SLPI, also known as antileukoprotease (ALP), is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).

Product Categories/Family for anti-SLPI antibody

Antibodies; Abs to Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 758101
• UniProt Accession #: P03973; P07757; B2R5H8
• Molecular Weight: 14,326 Da
• NCBI Official Full Name: secretory leukocyte protease inhibitor (SLPI)
• UniProt Protein Name: Antileukoproteinase
• Protein Family: Antileukoproteinase
• UniProt Gene Name: SLPI
• UniProt Synonym Gene Names: WAP4; WFDC4; ALP; MPI
• UniProt Entry Name: SLPI_HUMAN

Uniprot Description

SLPI: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: extracellular matrix

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; endopeptidase inhibitor activity

Biological Process: negative regulation of viral genome replication; negative regulation of protein binding