Testing Data
(Staining of CD223 transfected cells withMBS608941.)
Rat anti-Mouse LAG-3 Monoclonal Antibody | anti-LAG-3 antibody
LAG-3 (Lymphocyte Activation Gene-3, FDC Protein, CD223) (MaxLight 490)
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Purity
Purified by Protein G Affinity Chromatography
Synonyms
LAG-3; Monoclonal Antibody; LAG-3 (Lymphocyte Activation Gene-3; FDC Protein; CD223) (MaxLight 490); anti-LAG-3 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7E155
Specificity
Recognizes murine lymphocyte activation gene-3 (LAG-3). Recognizes an epitope within the D2 domain of CD223. Reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II.
Purity/Purification
Purified by Protein G Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight490.
Applicable Applications for anti-LAG-3 antibody
Flow Cytometry (FC/FACS)
Immunogen
Murine CD223 Ig fusion protein
Conjugate
MaxLight490
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Testing Data
(Staining of CD223 transfected cells withMBS608941.)
Testing Data
(Staining of CD223 transfected cells withMBS608941.)
Product Categories/Family for anti-LAG-3 antibody
References
1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur. J. Immunol. 32:2255-2263. 2. Workman, C.J. et al. (2005) Negative Regulation of T cell Homeostasis by Lymphocyte Activation gene-3 (CD223). J. Immunol.174:688-695 3. Byrne, K.T. et al. (2011) Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma. J Clin Invest. 121: 1797-809.
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Product Notes
The LAG-3 (Catalog #AAA6254036) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The LAG-3 (Lymphocyte Activation Gene-3, FDC Protein, CD223) (MaxLight 490) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LAG-3 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the LAG-3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAG-3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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