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Immunohistochemistry (IHC) (mmunohistochemistry Analysis: Representative lot data. Paraffin-embedded rat hippocampus tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:500 dilution of MBS633279 Reactivity was detected using the IHC-Select Detection Kit Tissue appears stained in the fields of Ammon's horn (regions CA1-3).)

Mouse anti-Mouse, Rat ATX1 Monoclonal Antibody | anti-ATX1 antibody

ATX1 (Ataxin 1) (MaxLight 550) [KO Validated]

Gene Names
Atxn1; Atx1; Sca1; C85907; Gm10786; 2900016G23Rik
Reactivity
Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Purified by Protein G Affinity Chromatography
Synonyms
ATX1; Monoclonal Antibody; ATX1 (Ataxin 1) (MaxLight 550) [KO Validated]; anti-ATX1 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
11C231
Specificity
Recognizes mouse Ataxin-1. Species crossreactivity: rat
Purity/Purification
Purified by Protein G Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Sequence Length
791
Applicable Applications for anti-ATX1 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Immunogen
Linear peptide corresponding to mouse Ataxin-1. Cellular Localization: Cytoplasm (By similarity). Nucleus. Note: Co-localizes with USP7 in the nucleus (By similarity).
Conjugate
MaxLight550
Preparation and Storage
Store at 4 degree C. Do Not Freeze.

Immunohistochemistry (IHC)

(mmunohistochemistry Analysis: Representative lot data. Paraffin-embedded rat hippocampus tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:500 dilution of MBS633279 Reactivity was detected using the IHC-Select Detection Kit Tissue appears stained in the fields of Ammon's horn (regions CA1-3).)

Immunohistochemistry (IHC) (mmunohistochemistry Analysis: Representative lot data. Paraffin-embedded rat hippocampus tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:500 dilution of MBS633279 Reactivity was detected using the IHC-Select Detection Kit Tissue appears stained in the fields of Ammon's horn (regions CA1-3).)

Immunohistochemistry (IHC)

(Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded rat cerebral cortex tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:500 dilution of MBS633279 Reactivity was detected using the IHC-Select Detection Kit Tissue appears stained in the polymorph layer dentate gyrus region of the hypothalamus. )

Immunohistochemistry (IHC) (Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded rat cerebral cortex tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:500 dilution of MBS633279 Reactivity was detected using the IHC-Select Detection Kit Tissue appears stained in the polymorph layer dentate gyrus region of the hypothalamus. )

Western Blot (WB)

(Western Blotting Analysis: Representative lot data. Two rat hippocampus tissue lysates, Ataxin-1 Knockout (lane 1) and Wildtype (lane 2), were probed with MBS633279 Arrow indicates Ataxin-1 (~ 85 kDa).)

Western Blot (WB) (Western Blotting Analysis: Representative lot data. Two rat hippocampus tissue lysates, Ataxin-1 Knockout (lane 1) and Wildtype (lane 2), were probed with MBS633279 Arrow indicates Ataxin-1 (~ 85 kDa).)
Product Categories/Family for anti-ATX1 antibody
References
1. Irwin, S., et al. (2005). J. Cell. Sci. 118:233- 242. 2. Bolger, T., et al. (2007). J. Biol. Chem. 282: 29186-29192.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
85
NCBI Official Full Name
ataxin-1 isoform b
NCBI Official Synonym Full Names
ataxin 1
NCBI Official Symbol
Atxn1
NCBI Official Synonym Symbols
Atx1; Sca1; C85907; Gm10786; 2900016G23Rik
NCBI Protein Information
ataxin-1
UniProt Protein Name
Ataxin-1
Protein Family
UniProt Gene Name
Atxn1
UniProt Synonym Gene Names
Sca1

Uniprot Description

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (). May be involved in RNA metabolism (). In concert with CIC and ATXN1L, involved in brain development (PubMed:28288114).

Research Articles on ATX1

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Product Notes

The ATX1 atxn1 (Catalog #AAA6246230) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ATX1 (Ataxin 1) (MaxLight 550) [KO Validated] reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ATX1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the ATX1 atxn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATX1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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