Rabbit anti-Rat Opioid Receptor, delta Polyclonal Antibody | anti-OPRD1 antibody

Opioid Receptor, delta (OPRD1, Opioid Receptor delta, Delta-type Opioid Receptor, DOR-1, OPRD)

Cat. Num. AAA624086

• Gene Names: OPRD1; OPRD
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Purified; Purified by precipitation, dialysis and chromatography.
• Synonyms: Opioid Receptor; delta; Polyclonal Antibody; delta (OPRD1; Opioid Receptor delta; Delta-type Opioid Receptor; DOR-1; OPRD); Anti -Opioid Receptor; anti-OPRD1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes delta Opioid Receptor (360-372) and the reactivity of delta Opioid Receptor is ~60%. Does not react to Mu Opioid Receptor and Kappa Opioid Receptor. Has been found to stain specifically the delta opioid receptor in Western immunoblots of whole rat brain homogenates.
• Purity/Purification: Purified; Purified by precipitation, dialysis and chromatography.
• Form/Format: Supplied as a lyophilized powder. Reconstitution with 5.0 ml of TBS/Tween-20 containing 1% normal goat serum.

• Applicable Applications for anti-OPRD1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:8 with TBS/Tween-20, 1% normal goat serum.
• Immunogen: Peptide analog of the carboxyl terminal of the delta opioid receptor covalently attached onto a carrier protein.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile TBS/Tween-20 containing 1% normal goat serum. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-OPRD1 antibody

The function of the delta-opioid receptors has not been determined. However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.

Product Categories/Family for anti-OPRD1 antibody

Antibodies; Abs to Opioid Receptors; Agonists

NCBI and Uniprot Product Information

• NCBI GI #: 119628077
• NCBI GeneID: 4985
• UniProt Accession #: P41143; B5B0B8
• Molecular Weight: 40,369 Da
• NCBI Official Full Name: opioid receptor, delta 1
• NCBI Official Synonym Full Names: opioid receptor, delta 1
• NCBI Official Symbol: OPRD1
• NCBI Official Synonym Symbols: OPRD
• NCBI Protein Information: delta-type opioid receptor; DOR-1; D-OR-1; OTTHUMP00000003778; delta opioid receptor 1
• UniProt Protein Name: Delta-type opioid receptor
• Protein Family: Delta-type opioid receptor
• UniProt Gene Name: OPRD1
• UniProt Synonym Gene Names: OPRD
• UniProt Entry Name: OPRD_HUMAN

Uniprot Description

DOR-1: delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.1-p34.3

Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; intrinsic to plasma membrane; vesicle; lipid raft

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: adult locomotory behavior; activation of CREB transcription factor; regulation of calcium ion transport; sensory perception of pain; positive regulation of peptidyl-serine phosphorylation; synaptic transmission; negative regulation of protein oligomerization; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; regulation of mitochondrial membrane potential; protein import into nucleus, translocation; neuropeptide signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of sensory perception of pain