Rabbit IPR1 Polyclonal Antibody

IPR1, CT (FLJ22835, IFI41, IFI75, Interferon-induced protein 41/75, IPR1, Sp110 nuclear body protein, Speckled 110kD, Transcriptional coactivator Sp110, VODI)

Cat. Num. AAA622899

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: IPR1; Polyclonal Antibody; CT (FLJ22835; IFI41; IFI75; Interferon-induced protein 41/75; Sp110 nuclear body protein; Speckled 110kD; Transcriptional coactivator Sp110; VODI); Anti -IPR1; anti-IPR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IPR1. Species crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-IPR1 antibody: Western Blot (WB)
• Application Notes: Dilution: Western Blot: 1-2ug/ml
• Immunogen: Synthetic peptide corresponding to 15aa from near the carboxy terminus of the human IPR1 (GenBank accession no. NP_004501).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of IPR1 in Hela cell lysate with IPR1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.)

Related Product Information for anti-IPR1 antibody

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene (1). IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator (1,2). Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans (2). The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis (1). IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis (3,4)

Product Categories/Family for anti-IPR1 antibody

Antibodies; Abs to Interferon

NCBI and Uniprot Product Information

• NCBI GI #: 57014053
• NCBI Official Full Name: intracellular pathogen resistance 1

Uniprot Description

SP110: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI). VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Cellular Component: nucleolus; nucleus

Molecular Function: DNA binding; chromatin binding

Biological Process: chromatin remodeling; transcription, DNA-dependent; response to bacterium; regulation of transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; immune system process; innate immune response