Sheep anti-Human, Rat Synuclein, pan Polyclonal Antibody
Synuclein, pan (Alpha Synuclein, Beta Synuclein, Breast Cancer Specific Gene 1 Protein, Breast Cancer-specific Gene 1 Protein, BCSG1, Gamma Synuclein, Gamma-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1,
Reactivity
Human, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Synuclein; pan; Polyclonal Antibody; pan (Alpha Synuclein; Beta Synuclein; Breast Cancer Specific Gene 1 Protein; Breast Cancer-specific Gene 1 Protein; BCSG1; Gamma Synuclein; Gamma-synuclein; Non-A beta Component of AD Amyloid; Non-A4 Component of Amyloid Precursor; NACP; PARK1; ; Anti -Synuclein; anti-Synuclein; pan antibody
Host
Sheep
Reactivity
Human, Rat
Clonality
Polyclonal
Specificity
Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins Species Crossreactivity: This antiserum recognizes human and rat alpha-, beta- and gamma synucleins.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Applicable Applications for anti-Synuclein, pan antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western Blot and Immunohistochemistry.
Immunogen
A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Synuclein, pan antibody
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).
Product Categories/Family for anti-Synuclein, pan antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
synuclein, gamma (breast cancer-specific protein 1)
Similar Products
Product Notes
The Synuclein, pan (Catalog #AAA620143) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The Synuclein, pan (Alpha Synuclein, Beta Synuclein, Breast Cancer Specific Gene 1 Protein, Breast Cancer-specific Gene 1 Protein, BCSG1, Gamma Synuclein, Gamma-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1, reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Synuclein, pan can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Researchers should empirically determine the suitability of the Synuclein, pan for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synuclein, pan, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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