Rabbit anti-Human Transcription Factor SP7 Polyclonal Antibody | anti-SP7 antibody
Transcription Factor SP7 (OSX, Osterix, Zinc Finger Protein Osterix)
Serum
Serum
Dilution: ELISA: 1:50,000-1:100,000
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
Uniprot Description
osterix: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. Defects in SP7 are the cause of osteogenesis imperfecta type 11 (OI11). A connective tissue disorder characterized by bone fragility, low bone mass, recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Belongs to the Sp1 C2H2-type zinc-finger protein family.
Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytoplasm; nucleus
Molecular Function: DEAD/H-box RNA helicase binding; DNA binding; metal ion binding
Biological Process: regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter
Disease: Osteogenesis Imperfecta, Type Xii
Research Articles on SP7
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Product Notes
The SP7 sp7 (Catalog #AAA619287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Transcription Factor SP7 (OSX, Osterix, Zinc Finger Protein Osterix) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Transcription Factor SP7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Dilution: ELISA: 1:50,000-1:100,000. Researchers should empirically determine the suitability of the SP7 sp7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transcription Factor SP7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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