Rabbit Protein Phosphotase 1, beta Polyclonal Antibody | anti-PPP1CB antibody

Protein Phosphotase 1, beta (Ser,Thr) (PP1b)

Cat. Num. AAA618461

• Gene Names: PPP1CB; PP-1B; PPP1CD; MGC3672; PP1beta
• Reactivity: Bovine, Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation
• Purity: Purified; Purified IgG
• Synonyms: Protein Phosphotase 1; beta; Polyclonal Antibody; beta (Ser; Thr) (PP1b); Anti -Protein Phosphotase 1; anti-PPP1CB antibody

• Host: Rabbit
• Reactivity: Bovine, Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes PP1beta (38kD). No crossreactivity with other recombinant PP1 isoforms. Species Crossreactiivity: Human, mouse, rat and bovine.
• Purity/Purification: Purified; Purified IgG
• Form/Format: Supplied as a liquid in PBS, 0.08% sodium azide.

• Applicable Applications for anti-PPP1CB antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.; Dilution: Western Blot: 5-10ug/ml; Optimum dilutions to be determined by researcher.
• Immunogen: Purified synthetic peptide corresponding to aa318-327 (NH2-Pro-Arg-Thr-Ala-Asn-Pro-Pro-Lys-Lys-Arg-COOH) within the C-terminus of PP1b (KLH coupled).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer..

Product Categories/Family for anti-PPP1CB antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 531476
• NCBI GeneID: 5500
• UniProt Accession #: P62140; P37140; Q5U087; Q6FG45; B2R5V4; D6W565
• Molecular Weight: 37,187 Da
• NCBI Official Full Name: protein phosphotase 1 catyltic subunit beta isoform
• NCBI Official Synonym Full Names: protein phosphatase 1, catalytic subunit, beta isozyme
• NCBI Official Symbol: PPP1CB
• NCBI Official Synonym Symbols: PP-1B; PPP1CD; MGC3672; PP1beta
• NCBI Protein Information: serine/threonine-protein phosphatase PP1-beta catalytic subunit; OTTHUMP00000200967; OTTHUMP00000200968; protein phosphatase 1-beta; protein phosphatase 1-delta; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase 1, catalytic subunit, delta isoform; serine/threonine protein phosphatase PP1-beta catalytic subunit
• UniProt Protein Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP1CB
• UniProt Entry Name: PP1B_HUMAN

NCBI Description

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Uniprot Description

PPP1CB: is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis; EC 3.1.3.53; Nucleolus

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: nucleoplasm; focal adhesion; glycogen granule; nucleolus; protein phosphatase type 1 complex; nucleus

Molecular Function: protein binding; myosin-light-chain-phosphatase activity; metal ion binding; phosphoric monoester hydrolase activity; protein kinase binding; myosin phosphatase activity

Biological Process: regulation of cell adhesion; glycogen metabolic process; regulation of glycogen biosynthetic process; protein amino acid dephosphorylation; regulation of circadian rhythm; entrainment of circadian clock by photoperiod; regulation of glycogen catabolic process; cell division; transforming growth factor beta receptor signaling pathway; triacylglycerol catabolic process; circadian regulation of gene expression; mitotic cell cycle; negative regulation of transforming growth factor beta receptor signaling pathway; G2/M transition of mitotic cell cycle