anti-Human Epithelial Sodium Channel, delta Polyclonal Antibody | anti-SCNN1D antibody

Anti - Epithelial Sodium Channel, delta (ENAC Delta)

Cat. Num. AAA618296

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum
• Synonyms: Epithelial Sodium Channel; delta; Polyclonal Antibody; Anti - Epithelial Sodium Channel; delta (ENAC Delta); anti-SCNN1D antibody

• Host: Host: Rabbit; Source: Human
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ENAC Delta. The 19 AA human control peptide sequence homology in various species is not known as ENAC d from other species are yet to be cloned. No significant homology is detected with ENAC alpha, beta, gamma subunits.
• Purity/Purification: Serum
• Form/Format: Serum; Supplied as a liquid (serum) in PBS, pH 7.2, containing 40% glycerol and 0.05% sodium azide.
• Concentration: ~1mg/ml (varies by lot)
• Sequence Length: 638

• Applicable Applications for anti-SCNN1D antibody: ELISA, Western Blot
• Application Notes: Suitable for use in ELISA and Western Blot. Other applications not tested.; Dilution: ELISA: 1:10,000-1:50,000. Control peptide (E3414-70H) can be used to coat ELISA plate at 1ug/ml; Western Blot: 1:1000-1:5000 using ECL technique.; Optimal dilutions to be determined by the researcher.
• Immunogen: A 19 amino acid peptide sequence near the N-terminus of human ENAC delta
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-SCNN1D antibody

Tissue acidosis (decrease in pH below the physiological level) that occurs in ischemia, tissue damage or inflammation is accompanied by pain. At the molecular level, H+-gated cation channels are activated by low pH in nociceptive neurons. H+-gated cation channels, members of the NaC/DEG superfamily of Na channels that include amiloride-sensitive epithelial Na+ channel proteins (alpha, beta, and gamma, and delta-ENaC subunits), are expressed in epithelia of the vertebrate kidney, colon, lung, tongue, and brain. The ENaC subunits may form heterotrimeric active Na channel. ENaCs are involved in Na and water readsorption, and salty taste transduction) of vertebrate colon, lung, kidney and tongue. The superfamily of DEG/NaC proteins are characterized by intracellular N and C-termini, two TM domains, and a large extracellular loop.

Product Categories/Family for anti-SCNN1D antibody

Abs to Ion Channel

References

• 1. Waldmann R et al (1995) J. Biol. Chem. 270:27411-27414.
• 2. Garty H and Palmer LG (1997) Physiol. Reviews. 77:359-396 (review).

NCBI and Uniprot Product Information

• NCBI GI #: 2724058
• NCBI GeneID: 450189
• UniProt Accession #: O46547
• Molecular Weight: 70,188 Da
• NCBI Official Full Name: epithelial sodium channel delta subunit
• NCBI Official Symbol: SCNN1D
• NCBI Protein Information: amiloride-sensitive sodium channel subunit delta; SCNED; delta-ENaC; delta-NaCH; epithelial Na(+) channel subunit delta; epithelial sodium channel delta subunit; nonvoltage-gated sodium channel 1 subunit delta
• UniProt Protein Name: Amiloride-sensitive sodium channel subunit delta
• Protein Family: Amiloride-sensitive sodium channel
• UniProt Gene Name: SCNN1D
• UniProt Synonym Gene Names: DNACH
• UniProt Entry Name: SCNND_PANTR