Mouse ALS2 Monoclonal Antibody | anti-ALS2 antibody

ALS2 (Amyotrophic Lateral Sclerosis 2 (juvenile), ALS2CR6, ALSJ, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ) (FITC)

Cat. Num. AAA6177813

• Gene Names: ALS2; ALSJ; PLSJ; IAHSP; ALS2CR6
• Applications: ELISA, Immunofluorescence, Western Blot
• Purity: Purified
• Synonyms: ALS2; Monoclonal Antibody; ALS2 (Amyotrophic Lateral Sclerosis 2 (juvenile); ALS2CR6; ALSJ; FLJ31851; IAHSP; KIAA1563; MGC87187; PLSJ) (FITC); Amyotrophic Lateral Sclerosis 2 (juvenile); PLSJ; anti-ALS2 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 4F10
• Specificity: Recognizes ALS2.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
• Sequence Length: 812

• Applicable Applications for anti-ALS2 antibody: ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: ALS2 (AAH29174, 221aa-320aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: PSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSS
• Conjugate: FITC
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.; ; FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunofluorescence (IF)

(Immunofluorescence of monoclonal antibody to ALS2 on HeLa cell. [antibody concentration 40 ug/ml])

Immunofluorescence (IF)

(Immunofluorescence of monoclonal antibody to ALS2 on HeLa cell. [antibody concentration 40 ug/ml])

Related Product Information for anti-ALS2 antibody

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Product Categories/Family for anti-ALS2 antibody

Antibodies; Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 20810130
• NCBI GeneID: 57679
• NCBI Official Full Name: ALS2 protein
• NCBI Official Synonym Full Names: alsin Rho guanine nucleotide exchange factor ALS2
• NCBI Official Symbol: ALS2
• NCBI Official Synonym Symbols: ALSJ; PLSJ; IAHSP; ALS2CR6
• NCBI Protein Information: alsin
• Protein Family: Alsin

NCBI Description

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]