Rabbit anti-Human Endoplasmic Reticulum Associated Amyloid Beta Binding Protein Polyclonal Antibody
Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (ERAB)
Reactivity
Human
Applications
ELISA, Western Blot
Purity
SerumSerum
Synonyms
Endoplasmic Reticulum Associated Amyloid Beta Binding Protein; Polyclonal Antibody; Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (ERAB); Anti -Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (ERAB); anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human ERAB. Species Sequence Homology
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a liquid in 0.05% sodium azide.
Applicable Applications for anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1:1000-1:5000. Detects ~27kD protein in the brain
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Dilution: Western Blot: 1:1000-1:5000. Detects ~27kD protein in the brain
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Immunogen
Synthetic peptide corresponding to a 14aa sequence from the middle portion of human ERAB.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody
An intracellular protein termed ERAB (262aa, Endoplasmic reticulum associated Ab binding protein on chromosome X) has been cloned and linked with Ab neurotoxicity. ERAB has structural homology with short-chain alcohol dehydrogenases (hydroxysteroid dehydrogenases and acetyl-CoA reductases). Interestingly, ERAB localizes to endoplasmic reticulum despite the absence of a classical transmembrane sequence. However, in the presence of Ab, ERAB-Ab complex translates to the inner plasma membrane. Alzheimer patients have strong ERAB activity. Normal brains have virtually no ERAB. In addition, Ab neurotoxicity can be reduced by blocking ERAB.
Product Categories/Family for anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody
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Product Notes
The Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (Catalog #AAA615689) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (ERAB) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Endoplasmic Reticulum Associated Amyloid Beta Binding Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot and ELISA. Dilution: Western Blot: 1:1000-1:5000. Detects ~27kD protein in the brain ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well. Researchers should empirically determine the suitability of the Endoplasmic Reticulum Associated Amyloid Beta Binding Protein for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Endoplasmic Reticulum Associated Amyloid Beta Binding Protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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