Western Blot (WB)
(Western Blot detection against Immunogen (37.73kD).)
Mouse anti-Human FANCB Monoclonal Antibody | anti-FANCB antibody
FANCB (Fanconi Anemia Group B Protein, Protein FACB, Fanconi Anemia-associated Polypeptide of 95kD, FAAP95) (HRP)
Western Blot (WB)
(Western Blot detection against Immunogen (37.73kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (37.73kD).)
Testing Data
(Detection limit for recombinant GST tagged FANCB is 3ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged FANCB is 3ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016]
Uniprot Description
Function: DNA repair protein required for FANCD2 ubiquitination. Ref.4
Subunit structure: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. Ref.4 Ref.5
Subcellular location: Nucleus Ref.4.
Involvement in disease: Fanconi anemia complementation group B (FANCB) [MIM:300514]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.6
Sequence caution: The sequence AAH43596.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence AAH55411.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
Research Articles on FANCB
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Product Notes
The FANCB fancb (Catalog #AAA6152445) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FANCB (Fanconi Anemia Group B Protein, Protein FACB, Fanconi Anemia-associated Polypeptide of 95kD, FAAP95) (HRP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FANCB can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the FANCB fancb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FANCB, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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