Rabbit anti-Human ADNP Polyclonal Antibody | anti-ADNP antibody

ADNP (Activity Dependent Neuroprotective Protein)

Cat. Num. AAA614729

• Gene Names: ADNP; ADNP1; KIAA0784
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ADNP; Polyclonal Antibody; ADNP (Activity Dependent Neuroprotective Protein); Anti -ADNP (Activity Dependent Neuroprotective Protein); anti-ADNP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Reacts with the human 114kD hADNP protein.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of 40% glycerol.

• Applicable Applications for anti-ADNP antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Western Blot: 1:250-1:500
• Immunogen: Human 114 kDA hADNP protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-ADNP antibody

The activity-dependent neuroprotective protein (ADNP) gene is frequently ampli ed in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. hADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. hADNP is implicated in maintaining cell survival, perhaps through modulation of p53. ADNP is a member of the protein family with a nine-zinc finger motif followed by a homeobox domain. The human ADNP (hADNP) mRNA is expressed in distinct normal tissues, while high expression levels are encountered in malignant cells. The hADNP gene is mapped to chromosome 20q12-13.2, a region amplified in neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. Inhibition of ADNP protein expression by antisense oligodeoxynucleotides results in reduction of cellular metabolic activity and increase in the tumor suppressor p53. Such results may suggest development of antisense ADNP oligodeoxynucleotides in antitumor therapeutics

Product Categories/Family for anti-ADNP antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger

NCBI and Uniprot Product Information

• NCBI GI #: 31563503
• NCBI GeneID: 23394
• NCBI Accession #: NP_852107.1
• NCBI GenBank Nucleotide #: NM_181442.1
• UniProt Accession #: Q6DHZ8; Q9H2P0
• Molecular Weight: 123,447 Da
• NCBI Official Full Name: activity-dependent neuroprotector homeobox protein
• NCBI Official Synonym Full Names: activity-dependent neuroprotector homeobox
• NCBI Official Symbol: ADNP
• NCBI Official Synonym Symbols: ADNP1; KIAA0784
• NCBI Protein Information: activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; OTTHUMP00000031275; OTTHUMP00000031276; OTTHUMP00000165329; OTTHUMP00000229415; activity-dependent neuroprotective protein
• UniProt Protein Name: Activity-dependent neuroprotector homeobox
• Protein Family: ADNP homeobox protein
• UniProt Gene Name: ADNP
• UniProt Entry Name: Q6DHZ8_HUMAN

NCBI Description

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]

Uniprot Description

ADNP: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Protein type: C2H2-type zinc finger protein; DNA-binding; Apoptosis

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: extracellular space; nucleus

Molecular Function: protein binding; DNA binding; metal ion binding; chromatin binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of neuron apoptosis

Disease: Mental Retardation, Autosomal Dominant 28