Mouse anti-Human PRRG2 Monoclonal Antibody | anti-PRRG2 antibody

PRRG2 (Transmembrane gamma-carboxyglutamic Acid Protein 2, Proline-rich gamma-carboxyglutamic Acid Protein 2, Proline-rich Gla Protein 2, PRGP2, TMG2) (Biotin)

Cat. Num. AAA6143773

• Gene Names: PRRG2; PRGP2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PRRG2; Monoclonal Antibody; PRRG2 (Transmembrane gamma-carboxyglutamic Acid Protein 2; Proline-rich gamma-carboxyglutamic Acid Protein 2; Proline-rich Gla Protein 2; PRGP2; TMG2) (Biotin); anti-PRRG2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 7D1
• Specificity: Recognizes human PRRG2.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-PRRG2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa50-110, from human PRRG2 (NP_000942) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: ANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVAS
• Conjugate: Biotin
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged PRRG2 is 0.03ng/ml as a capture antibody.)

Product Categories/Family for anti-PRRG2 antibody

Antibodies; Transmembrane Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4506137
• NCBI GeneID: 5639
• NCBI Accession #: NP_000942
• NCBI GenBank Nucleotide #: NM_000951
• UniProt Accession #: O14669
• Molecular Weight: 22
• NCBI Official Full Name: transmembrane gamma-carboxyglutamic acid protein 2 isoform 1
• NCBI Official Synonym Full Names: proline rich and Gla domain 2
• NCBI Official Symbol: PRRG2
• NCBI Official Synonym Symbols: PRGP2
• NCBI Protein Information: transmembrane gamma-carboxyglutamic acid protein 2
• UniProt Protein Name: Transmembrane gamma-carboxyglutamic acid protein 2
• Protein Family: Transmembrane gamma-carboxyglutamic acid protein
• UniProt Gene Name: PRRG2
• UniProt Synonym Gene Names: PRGP2; TMG2; Proline-rich Gla protein 2
• UniProt Entry Name: TMG2_HUMAN

NCBI Description

The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Description

Subunit structure: Interacts with NEDD4

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Highly expressed in the thyroid.

Post-translational modification: Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Sequence similarities: Contains 1 Gla (gamma-carboxy-glutamate) domain.